FlyBase Allele Report: Dmel\CG6015[HMS01037]

General Information

Symbol

Dmel\CG6015^HMS01037

Species

D. melanogaster

Name

FlyBase ID

FBal0257703

Feature type

allele

Associated gene

Dmel\CG6015

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01037}

Also Known As

UAS-CG6015 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01037}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01037

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by Rbf^HMS03004

(Parkhitko et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

cyst cell of testis | absent, with Scer\GAL4^NP1624

(Zheng et al., 2021)

cyst cell of testis | increased number, with Scer\GAL4^bam.PU

(Yu et al., 2021)

cyst progenitor cell | absent, with Scer\GAL4^NP1624

(Zheng et al., 2021)

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

male fusome, with Scer\GAL4^bam.PU

(Yu et al., 2021)

male fusome, with Scer\GAL4^NP1624

(Zheng et al., 2021)

male germline cell, with Scer\GAL4^bam.PU

(Yu et al., 2021)

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

spermatid, with Scer\GAL4^bam.PU

(Yu et al., 2021)

Detailed Description

Statement

Reference

Expressing CG6015^HMS01037 under the control of Scer\GAL4^Cg.PA leads to fragmented and clustered mitochondria in the third instar larval fat body (as assessed by MitoGFP).

(Zhou et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

CG6015^HMS01037, Scer\GAL4^bam.PU, bam^Δ86 has increased cell number | spermatogenesis phenotype

(Yu et al., 2021)

CG6015^HMS01037, Scer\GAL4^bam.PU, bam^Δ86 has increased occurrence of cell division | spermatogenesis phenotype

(Yu et al., 2021)

Phenotype Manifest In

Enhanced by

Statement

Reference

CG6015^HMS01037, Scer\GAL4^bam.PU has male germline cell phenotype, enhanceable by bam^Δ86

(Yu et al., 2021)

Other

Statement

Reference

CG6015^HMS01037, Scer\GAL4^bam.PU, bam^Δ86 has spermatid phenotype

(Yu et al., 2021)

CG6015^HMS01037, Scer\GAL4^bam.PU, bam^Δ86 has male germline cell phenotype

(Yu et al., 2021)

CG6015^HMS01037, Scer\GAL4^bam.PU, bam^Δ86 has male fusome phenotype

(Yu et al., 2021)

CG6015^HMS01037, Scer\GAL4^bam.PU, bam^Δ86 has cyst cell of testis | increased number phenotype

(Yu et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

34565

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01037}attP2

NIG-Fly

HMS01037

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01037}attP2

Notes on Origin

Discoverer

Comments

Supplemental Dataset_S01.

(Yan and Perrimon, 2015)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CG6015^HMS01037

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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