FlyBase Allele Report: Scer\GAL4[iav.PK]

General Information

Symbol

Scer\GAL4^iav.PK

Species

S. cerevisiae

Name

inactive promoter construct of Kwon

FlyBase ID

FBal0246488

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

Carried in Construct

P{iav-GAL4.K}

Also Known As

iav-GAL4

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Kwon et al., 2010)

Progenitor genotype

Carried in construct

P{iav-GAL4.K}

Cytology

Description

Approximately 3kb of sequence flanking the 5' end of iav regulates expression of a GAL4 driver.

(Kwon et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

iav

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

chordotonal neuron | subset

(Kwon et al., 2010)

adult stage

chordotonal neuron of chordotonal organ of leg

(Lacin et al., 2020)

mechanosensory neuron of femoral chordotonal organ

(Agrawal et al., 2020)

adult chordotonal neuron

(Dhakal et al., 2022, Zhang et al., 2020)

Additional Information

Statement

Reference

Drives expression in sensory chordotonal neurons

(FlyBase Curators, 2017)

Marker for

adult chordotonal neuron

(Zhang et al., 2020)

Reflects expression of

iav

(Lacin et al., 2020, Zhang et al., 2020, Kwon et al., 2010)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | larval stage, with Ctet\tetX^TNT-LC.UAS

(Wu et al., 2011)

abnormal behavior | larval stage, with PlexB^{EcTM.UAS.Tag:MYC}

(Wu et al., 2011)

abnormal gravitaxis | adult stage | progressive, with Gucy2d^HM05010

(Werner et al., 2024)

abnormal gravitaxis | adult stage | progressive, with nompB^JF03080

(Werner et al., 2024)

abnormal locomotor behavior | adult stage, with Hsap\KCNJ2^UAS.EGFP

(Tsubouchi et al., 2017)

abnormal locomotor behavior | larval stage | conditional, with Crei\ChR2^UAS.cSa

(Vogelstein et al., 2014)

abnormal neuroanatomy | embryonic stage, with PlexB^{EcTM.UAS.Tag:MYC}

(Wu et al., 2011)

abnormal thermotaxis | larval stage, with bishu-2^KK112067

(Deng et al., 2025)

abnormal thermotaxis | larval stage, with Dgat2^GD1854

(Deng et al., 2025)

abnormal thermotaxis | third instar larval stage, with Ctet\tetX^TNT-LC.UAS

(Kwon et al., 2010)

abnormal touch perception | third instar larval stage | heat sensitive, with shi^1.UAS

(Zhou et al., 2012)

abnormal touch response | third instar larval stage | heat sensitive, with shi^1.UAS

(Zhou et al., 2012)

decreased rate of adult locomotory behavior, with baz^JF01079

(Yeh et al., 2024)

decreased rate of adult locomotory behavior, with insc^HMJ22537

(Yeh et al., 2024)

decreased rate of adult locomotory behavior, with pins^HMJ21351

(Yeh et al., 2024)

Phenotype Manifest In

chordotonal neuron, with PlexB^{EcTM.UAS.Tag:MYC}

(Wu et al., 2011)

Detailed Description

Statement

Reference

Inhibition (using Hsap\KCNJ2^UAS.EGFP) of Scer\GAL4^iav.PK neurons in adults results in a significant reduction in wind-induced suppression of locomotion, compared to controls, with no effect on basal walking speed.

(Tsubouchi et al., 2017)

Optogenetic activation (using Crei\ChR2^UAS.cSa with 470 nm (blue) light) of Scer\GAL4^iav.PK cells in larvae results in a significant increase in turn-avoid behaviors, compared to controls.

(Vogelstein et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^iav.PK/Motor^KK111674 is a suppressor of decreased rate of larval locomotory behavior phenotype of mir-2b-1^KO

(Menzies et al., 2024)

Phenotype Manifest In