FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Zzzz\CAG127Q.GMR.Tag:HA
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General Information
Symbol
Zzzz\CAG127Q.GMR.Tag:HA
Species
a. artificial
Name
FlyBase ID
FBal0241465
Feature type
allele
Associated gene
Zzzz\CAG
Associated Insertion(s)
Carried in Construct
P{GMR-127Q.HA}
Transgenic product class
trinucleotide_repeat_expansion
(Kazemi-Esfarjani and Benzer, 2002)
Mutagen
Nature of the Allele
Transgenic product class
trinucleotide_repeat_expansion
(Kazemi-Esfarjani and Benzer, 2002)
Mutagen
in vitro construct
(Kazemi-Esfarjani and Benzer, 2002)
Progenitor genotype
Carried in construct
P{GMR-127Q.HA}
Cytology
Description

GMR regulatory sequences (five copies of a gl response element) drive expression of a 127 amino acid polyglutamine repeat, which is tagged at the C-terminal end with Tag:HA.

(Kazemi-Esfarjani and Benzer, 2002)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
Zzzz\CAG
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Zzzz\CAG127Q.GMR.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF have dramatically reduced pigmentation in the eye.

      (Fayazi et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4GMR.PF, Zzzz\CAG127Q.GMR.Tag:HA has visible phenotype, non-suppressible by mrj1GR.cFa

      (Fayazi et al., 2006)

      Scer\GAL4GMR.PF, Zzzz\CAG127Q.GMR.Tag:HA has visible phenotype, non-suppressible by mrj2GR.cFa

      (Fayazi et al., 2006)
      Phenotype Manifest In
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of either mrj1GR.cFa or mrj2GR.cFa does not suppress the loss of eye pigmentation caused by expression of Zzzz\CAG127Q.GMR.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF.

      Co-expression of either mrjEU639, mrjGMR.PF or mrjScer\UAS.cFa suppresses the loss of eye pigmentation caused by expression of Zzzz\CAG127Q.GMR.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF.

      (Fayazi et al., 2006)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      GMR5x.Zzzz\CAG.127Q
      Zzzz\CAG127Q.GMR.T:Ivir\HA1
      Zzzz\CAG127Q.GMR.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)