FlyBase Allele Report: Dmel\Lon[GD14030]

General Information

Symbol

Dmel\Lon^GD14030

Species

D. melanogaster

Name

FlyBase ID

FBal0206000

Feature type

allele

Associated gene

Dmel\Lon

Associated Insertion(s)

Carried in Construct

P{GD14030}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD14030}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD14030

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of CODAS syndrome

CEA

(Pareek et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of CODAS syndrome

is ameliorated by ClpP^{UAS.Tag:FLAG,Tag:HA}

(Pareek et al., 2018)

exacerbates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^{A315T.UAS.RFP(Unk)}

(Wang et al., 2019)

modeled by Hsap\TARDBP^{UAS.Tag:HA,RFP(Unk)}

(Wang et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | RU486 conditional, with Scer\GAL4^da.Switch.PT

(Rera et al., 2010)

abnormal flight, with Scer\GAL4^da.PU, Scer\GAL4^elav.PU

(Pareek et al., 2018)

abnormal locomotor behavior | adult stage, with Scer\GAL4^da.PU, Scer\GAL4^elav.PU

(Pareek et al., 2018)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

(Pareek et al., 2018)

fertile, with Scer\GAL4^da.PU, Scer\GAL4^elav.PU

(Pareek et al., 2018)

flightless, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

short lived, with Scer\GAL4^da.PU, Scer\GAL4^elav.PU

(Pareek et al., 2018)

short lived | female | RU486 conditional, with Scer\GAL4^da.Switch.PT

(Rera et al., 2010)

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

short lived | male | RU486 conditional, with Scer\GAL4^da.Switch.PT

(Rera et al., 2010)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^da.PU, Scer\GAL4^elav.PU

(Pareek et al., 2018)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

trichogen cell, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Adults expressing Lon^GD14030 under the combined control of Scer\GAL4^elav.PU, Scer\GAL4^da.PU exhibit significantly decreased flight (mild) and climbing abilities, as compared to controls. Adults expressing Lon^GD14030 under the control of Scer\GAL4^elav.PU alone also exhibit a significantly decreased climbing activity, albeit less severe.

(Pareek et al., 2018)

Expression of Lon^GD14030 under the control of Scer\GAL4^ey.PH has no detectable effect on eye structure.

(Thomas et al., 2014)

Adults expressing Lon^GD14030 under the control of the cardioblast-specific Scer\GAL4^tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

(Neely et al., 2010)

Adults expressing Lon^GD14030 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression of CG8798^GD14030 under the control of Scer\GAL4^da.Switch.PT in the presence of 20μ/ml RU486 results in a prolonged developmental phase compared to controls.

Expression of CG8798^GD14030 under the control of Scer\GAL4^da.Switch.PT in the presence of 20μ/ml RU486 does not result in a significant change in body weight in male flies.

Expression of CG8798^GD14030 under the control of Scer\GAL4^da.Switch.PT in the presence of 20μ/ml significantly reduces adult lifespan compared to controls in both males and females.

(Rera et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in grossly normal adult indirect flight muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in morphologically wild-type myofibrils in the adult indirect flight muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in wild-type sarcomeres in the adult indirect flight muscles.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in bristle morphology defects on the notum in 0% or 20-30% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14030

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Lon^GD14030, Scer\GAL4^da.PU, Scer\GAL4^elav.PU has abnormal locomotor behavior | adult stage phenotype, enhanceable by ClpP^{UAS.Tag:FLAG,Tag:HA}, Scer\GAL4^da.PU, Scer\GAL4^elav.PU

(Pareek et al., 2018)

Suppressed by

Statement

Reference

Lon^GD14030, Scer\GAL4^elav.PU has abnormal locomotor behavior | adult stage phenotype, suppressible by ClpP^{UAS.Tag:FLAG,Tag:HA}, Scer\GAL4^elav.PU

(Pareek et al., 2018)

Enhancer of

Statement

Reference

Lon^GD14030, Scer\GAL4^ey.PH is an enhancer of visible phenotype of Pink1^UAS.Tag:HA, Scer\GAL4^ey.PH

(Thomas et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

Lon^GD14030, Scer\GAL4^ey.PH is an enhancer of eye phenotype of Pink1^UAS.Tag:HA, Scer\GAL4^ey.PH

(Thomas et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Lon^GD14030 enhances the disorganised eye phenotype seen when Pink1^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^ey.PH.

(Thomas et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v36035

w¹¹¹⁸; P{GD14030}v36035

v36036

w¹¹¹⁸; P{GD14030}v36036

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14030

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG8798^GD14030

CG8798^v36035

(Rera et al., 2010)

Lon^GD14030

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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