FlyBase Allele Report: Dmel\Dora[GD6527]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Dora^GD6527

General Information

Symbol

Dmel\Dora^GD6527

Species

D. melanogaster

Name

FlyBase ID

FBal0203925

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

Transgenic product class

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

visible | adult stage, with Scer\GAL4^ey.PU

(Molina-Pelayo et al., 2022)

visible | adult stage, with Scer\GAL4^pnr.PU

(Molina-Pelayo et al., 2022)

visible | adult stage, with Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Phenotype Manifest In

arista lateral, with Scer\GAL4^ey.PU

(Molina-Pelayo et al., 2022)

mesonotum | adult stage, with Scer\GAL4^pnr.PU

(Molina-Pelayo et al., 2022)

trichogen cell, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

wing hair | absent, with Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Detailed Description

Statement

Reference

Adults expressing CG34401^GD6527 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) show significantly reduced avoidance of noxious temperature (46[o]C) compared to control flies.

Adults expressing CG34401^GD6527 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) show no significant change in the kinetics of high temperature (46[o]C) induced paralysis compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in loss of bristles on the notum in 0% or 10-20% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in bristle morphology defects on the notum in 10-20% or 40-50% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

6527

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, non-enhanceable by WASp^GD1559, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, non-enhanceable by DAAM^UASp.cMa, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Suppressed by

Statement

Reference

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, suppressible by Arp2^GD14716, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, suppressible by Arp3^GD12273, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, suppressible by SCAR^GD11380, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, suppressible by Act5C^UASp.GFP, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, suppressible | partially by capu^UASp.GFP, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, suppressible | partially by Abi^UASp.mCherry, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, suppressible by mwh^GD8165, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, suppressible by dia^UASp.EGFP, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, suppressible by sha^UAS.GFP, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, suppressible by chic^otu.PW

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, suppressible by ena^{UASp.B.mCherry}, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

NOT suppressed by

Statement

Reference

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, non-suppressible by WASp^GD1559, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has visible | adult stage phenotype, non-suppressible by DAAM^UASp.cMa, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Other

Statement

Reference

Dora^GD6527, Scer\GAL4^ptc.PU, mwh^GD8165 has visible | adult stage phenotype

(Molina-Pelayo et al., 2022)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, non-enhanceable by WASp^GD1559, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, non-enhanceable by DAAM^UASp.cMa, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Suppressed by

Statement

Reference

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, suppressible by dia^UASp.EGFP, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, suppressible by chic^otu.PW

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, suppressible by sha^UAS.GFP, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, suppressible by ena^{UASp.B.mCherry}, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, suppressible by Arp2^GD14716, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, suppressible by Arp3^GD12273, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, suppressible by SCAR^GD11380, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, suppressible by Act5C^UASp.GFP, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, suppressible | partially by capu^UASp.GFP, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, suppressible | partially by Abi^UASp.mCherry, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, suppressible by mwh^GD8165, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

NOT suppressed by

Statement

Reference

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, non-suppressible by WASp^GD1559, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^ptc.PU has wing hair phenotype, non-suppressible by DAAM^UASp.cMa, Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Suppressor of

Statement

Reference

Dora^GD6527, Scer\GAL4^Hml.PU is a suppressor of hemocyte phenotype of Cdc42^V12.UAS, Scer\GAL4^Hml.PU

(Molina-Pelayo et al., 2022)

Dora^GD6527, Scer\GAL4^Hml.PU is a suppressor of filopodium | increased number phenotype of Cdc42^V12.UAS, Scer\GAL4^Hml.PU

(Molina-Pelayo et al., 2022)

Other

Statement

Reference

Dora^GD6527, Scer\GAL4^ptc.PU, mwh^GD8165 has wing hair phenotype

(Molina-Pelayo et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Not rescued by

Dora^GD6527 is not rescued by Dora^{ΔC.UAS.Tag:HA}/Scer\GAL4^ptc.PU

(Molina-Pelayo et al., 2022)

Rescues

Dora^GD6527/Scer\GAL4^Hml.PU rescues Dora^{WT.UAS.Tag:HA}

(Molina-Pelayo et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

v18553

w¹¹¹⁸; P{GD6527}v18553

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

6527

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG34401^GD6527

Dora^GD6527

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections