FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\trr3
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General Information
Symbol
Dmel\trr3
Species
D. melanogaster
Name
FlyBase ID
FBal0151367
Feature type
allele
Associated gene
Dmel\trr
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: C2132T.

    (Sedkov et al., 2003)

    Amino acid replacement: ??term.

    (Sedkov et al., 2003)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  Huntington's disease
        modeled by Hsap\HTTQ93.ex1.UAS
        (Song et al., 2018)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Eggs derived from trr3 germline clones exhibit dramatically decreased hatching, as almost all fertilized eggs fail to initiate embryogenesis due to defects both in sperm chromatin unpacking and female meiotic completion.

        (Prudêncio et al., 2018)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        trr3 is an enhancer of lethal phenotype of EcRB1-ΔC655.F645A.UAS, Scer\GAL4GMR.PF

        (Sedkov et al., 2003)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The lethality seen in EcRB1-ΔC655.F645A.Scer\UAS, Scer\GAL4GMR.PF animals is enhanced by the addition of trr3/+.

        (Sedkov et al., 2003)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        dMLL3/4ΔSET
        (Prudêncio et al., 2018)
        trr3
        (Prudêncio et al., 2018, Song et al., 2018)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)