FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gβ13Ff261
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General Information
Symbol
Dmel\Gβ13Ff261
Species
D. melanogaster
Name
FlyBase ID
FBal0147910
Feature type
allele
Associated gene
Dmel\Gβ13F
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: G?T.

    (Fuse et al., 2003)

    Amino acid replacement: E38term.

    (Fuse et al., 2003)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:15,861,885..15,861,885 [+]
    Nucleotide change:

    G15861885T

    Reported nucleotide change:

    G?T

    Amino acid change:

    E38term | Gbeta13F-PA; E38term | Gbeta13F-PC; E38term | Gbeta13F-PE; E38term | Gbeta13F-PF; E38term | Gbeta13F-PG; E38term | Gbeta13F-PH

    Reported amino acid change:

    E38term

    (Fuse et al., 2003)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Stage 8 homozygous embryos derived from homozygous female germline clones show defects in gastrulation.

        64% of telophase neuroblasts divide into two similar-sized daughter cells in homozygous embryos derived from homozygous female germline clones.

        The number of EL neurons per hemisegment is reduced compared to wild type in homozygous embryos derived from homozygous female germline clones.

        (Wang et al., 2005)

        In mutants that are both maternally and zygotically mutant neuroblasts produce nearly equal sized daughters (in contrast to wild-type where daughters are unequal in size), though the GMC is still slightly smaller than the sibling neuroblast after the initial divisions. This abnormal division causes neuroblasts to be smaller and smaller after each successive division. By stage 14 fewer neuroblasts divide in mutants than in wild-type embryos. The number of EL neurons produced by neuroblast 3-3 is reduced from the normal 10 to 5. In mutant neuroblasts, spindle and astral microtubules develop well from both centrosomes as though both spindle halves are apical. Spindle asymmetry is also abolished in mutants. However the spindle position shifts towards the side where mira localises. These defects in neural development are rescued by a paternal supply of Gβ13F.

        (Fuse et al., 2003)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Neuroblasts of double mutant ric8aP587 ; Gβ13Ff261 embryos derived from double mutant ric8aP587 ; Gβ13Ff261 female germline clones show phenotypes similar to that seen in ric8aP587 homozygous embryos derived from ric8aP587 homozygous female germline clones.

        (Wang et al., 2005)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        Gβ13Ff261 is partially rescued by Scer\GAL4pros.PMG/Gβ13FUAS.cFa

        (Fuse et al., 2003)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Gβ13Ff261
        (Wang et al., 2005)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)