FlyBase Allele Report: Dmel\ptc[UAS.Tag:MYC]

General Information

Symbol

Dmel\ptc^UAS.Tag:MYC

Species

D. melanogaster

Name

FlyBase ID

FBal0146881

Feature type

allele

Associated gene

Dmel\ptc

Associated Insertion(s)

Carried in Construct

P{UAS-ptc.wt-myc}

Key Links

Transgenic product class

wild_type

(Vegh and Basler, 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Vegh and Basler, 2003)

Mutagen

in vitro construct

(Vegh and Basler, 2003)

Progenitor genotype

Carried in construct

P{UAS-ptc.wt-myc}

Cytology

Description

UASt regulatory sequences drive expression of wild-type ptc tagged at the N-terminal end with Tag:MYC.

(Vegh and Basler, 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

ptc

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^salm.E

(Mosimann et al., 2009)

Phenotype Manifest In

wing blade, with Scer\GAL4^salm.E

(Mosimann et al., 2009)

Detailed Description

Statement

Reference

Expression of ptc^{Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^salm.E results in growth and patterning defects in the intervein area between L2 and L5.

(Mosimann et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^salm.E, ptc^UAS.Tag:MYC has visible phenotype, non-enhanceable by Scer\GAL4^salm.E/hyx¹

(Mosimann et al., 2009)

Scer\GAL4^salm.E, ptc^UAS.Tag:MYC has visible phenotype, non-enhanceable by Scer\GAL4^salm.E/hyx²

(Mosimann et al., 2009)

Suppressed by

Statement

Reference

Scer\GAL4^salm.E, ptc^UAS.Tag:MYC has visible phenotype, suppressible | partially by hyx^UAS.cMa/Scer\GAL4^salm.E

(Mosimann et al., 2009)

Scer\GAL4^salm.E, ptc^UAS.Tag:MYC has visible phenotype, suppressible | partially by Scer\GAL4^salm.E/hyx^EP9

(Mosimann et al., 2009)

NOT suppressed by

Statement

Reference

Scer\GAL4^salm.E, ptc^UAS.Tag:MYC has visible phenotype, non-suppressible by Scer\GAL4^salm.E/hyx¹

(Mosimann et al., 2009)

Scer\GAL4^salm.E, ptc^UAS.Tag:MYC has visible phenotype, non-suppressible by Scer\GAL4^salm.E/hyx²

(Mosimann et al., 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^salm.E, ptc^UAS.Tag:MYC has wing blade phenotype, suppressible | partially by hyx^UAS.cMa/Scer\GAL4^salm.E

(Mosimann et al., 2009)

Scer\GAL4^salm.E, ptc^UAS.Tag:MYC has wing blade phenotype, suppressible | partially by Scer\GAL4^salm.E/hyx^EP9

(Mosimann et al., 2009)

NOT suppressed by

Statement

Reference

Scer\GAL4^salm.E, ptc^UAS.Tag:MYC has wing blade phenotype, non-suppressible by Scer\GAL4^salm.E/hyx¹

(Mosimann et al., 2009)

Scer\GAL4^salm.E, ptc^UAS.Tag:MYC has wing blade phenotype, non-suppressible by Scer\GAL4^salm.E/hyx²

(Mosimann et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of either hyx^Scer\UAS.cMa or hyx^EP9 leads to a partial rescue of the L2-L5 intervein growth and patterning defects caused by expression of ptc^{Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^salm.E.

The presence of either hyx¹ or hyx² mutant background has no effect on the L2-L5 intervein growth and patterning defects resulting from the expression of ptc^{Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^salm.E.

(Mosimann et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ptc^{Scer\UAS.T:Hsap\MYC}

ptc^UAS.Tag:MYC

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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