FlyBase Allele Report: Dmel\slmb[UAS.cGa]

General Information

Symbol

Dmel\slmb^UAS.cGa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Grima

FlyBase ID

FBal0140922

Feature type

allele

Associated gene

Dmel\slmb

Associated Insertion(s)

Carried in Construct

P{UAS-slmb.G}

Also Known As

UAS-slmb, UAS-slimb

Key Links

Transgenic product class

cDNA

(Grima et al., 2002)

wild_type

(Grima et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Grima et al., 2002)

wild_type

(Grima et al., 2002)

Mutagen

in vitro construct

(Grima et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-slmb.G}

Cytology

Description

UASt sequences drive expression of a slmb cDNA.

(Grima et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

slmb

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{N548.Q128.UAS}

(Godin et al., 2010)

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TAF15^UAS.cCa

(Choi et al., 2021)

exacerbates human immunodeficiency virus infectious disease

modeled by HIV-1\Vpu^UAS.cLa

(Marchal et al., 2012)

ameliorates tauopathy

modeled by Hsap\MAPT^{R406W.S2A.UAS.0N4R}

(Lee et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm, with Scer\GAL4¹¹¹⁸

(Grima et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of slmb^UAS.cGa under the control of Scer\GAL4^mex1.2.1 leads to an increase in survival on normal or CuCl2-supplemented food when compared to controls.

(Zhang et al., 2020)

Females that express slmb^Scer\UAS.cGa under the control of Scer\GAL4^CY2 produce wild-type egg chambers.

(Muzzopappa and Wappner, 2005)

When slmb^Scer\UAS.cGa is driven by Scer\GAL4¹¹¹⁸ the mean period of rhythmic flies increases from a average 0f 24 hours to a mean of 26.7 hours.

(Grima et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-enhancer of visible | adult stage phenotype of ATP7^KK100396, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-enhancer of visible | adult stage phenotype of ATP7^UAS.Tag:FLAG, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-enhancer of visible | adult stage phenotype of Ctr1A^GD16726, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

Suppressor of

Statement

Reference

slmb^UAS.cGa, Scer\GAL4^GMR.PU is a suppressor | partially of visible phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^GMR.PU

(Godin et al., 2010)

slmb^UAS.cGa, Scer\GAL4^GMR.PU is a suppressor | partially of abnormal eye color phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^GMR.PU

(Godin et al., 2010)

NOT Suppressor of

Statement

Reference

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-suppressor of visible | adult stage phenotype of ATP7^KK100396, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-suppressor of visible | adult stage phenotype of Ctr1A^GD16726, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-suppressor of visible | adult stage phenotype of ATP7^UAS.Tag:FLAG, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^dpp.blk1 is a non-suppressor of visible phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-enhancer of adult thorax phenotype of ATP7^KK100396, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-enhancer of adult thorax phenotype of ATP7^UAS.Tag:FLAG, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-enhancer of macrochaeta | absent phenotype of ATP7^UAS.Tag:FLAG, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-enhancer of microchaeta | absent phenotype of ATP7^UAS.Tag:FLAG, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-enhancer of adult thorax phenotype of Ctr1A^GD16726, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

Suppressor of

Statement

Reference

slmb^UAS.cGa, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^GMR.PU

(Godin et al., 2010)

slmb^UAS.cGa, Scer\GAL4^GMR.PU is a suppressor | partially of ommatidium phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^GMR.PU

(Godin et al., 2010)

slmb^UAS.cGa/Scer\GAL4^CY2 is a suppressor of egg operculum phenotype of Scer\GAL4^CY2, dpp^UAS.cRa

(Muzzopappa and Wappner, 2005)

NOT Suppressor of

Statement

Reference

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-suppressor of adult thorax phenotype of ATP7^KK100396, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-suppressor of adult thorax phenotype of Ctr1A^GD16726, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-suppressor of adult thorax phenotype of ATP7^UAS.Tag:FLAG, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-suppressor of macrochaeta | absent phenotype of ATP7^UAS.Tag:FLAG, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^pnr-MD237 is a non-suppressor of microchaeta | absent phenotype of ATP7^UAS.Tag:FLAG, Scer\GAL4^pnr-MD237

(Zhang et al., 2020)

slmb^UAS.cGa, Scer\GAL4^dpp.blk1 is a non-suppressor of wing phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

slmb^Scer\UAS.cGa overexpression suppresses the expanded operculum phenotype of eggs laid by females overexpressing dpp^Scer\UAS.cRa under the control of Scer\GAL4^CY2.

(Muzzopappa and Wappner, 2005)

Xenogenetic Interactions

Statement

Reference

Co-expression of slmb^Scer\UAS.cGa does not suppress the wing defects caused by expression of HIV-1\Vpu^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1.

(Marchal et al., 2012)

Co-expression of slmb^Scer\UAS.cGa decreases the loss of eye pigmentation and improves ommatidial morphology in flies expressing Hsap\HTT^{Q128.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Godin et al., 2010)

Complementation and Rescue Data

Rescues

slmb^UAS.cGa/Scer\GAL4^pnr-MD237 rescues slmb^KK108569

(Zhang et al., 2020)

Comments

The addition of slmb^Scer\UAS.cGa driven by Scer\GAL4^P2.4.Pdf or Scer\GAL4¹¹¹⁸ rescues this arrhythmia phenotype seen in those mutants in DD cycles.

(Grima et al., 2002)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

slmb^Scer\UAS.cGa

slmb^UAS.cGa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Grima

(Grima et al., 2002)

Secondary FlyBase IDs

References (9)

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