FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pakunspecified
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General Information
Symbol
Dmel\Pakunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0098331
Feature type
allele
Associated gene
Dmel\Pak
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The initial stages of mesoderm spreading during mesoderm morphogenesis are normal in mutant embryos, although the adhesion of the mesoderm to the ectoderm is affected at later stages.

        (Wilson et al., 2005)

        The gross morphology of Pakunspecified mutant synapses is normal, although there appears to be an increase in the variability of bouton size and number.

        (Albin and Davis, 2004)

        The phenotype caused by expression of msnEP549 under the control of Scer\GAL4GMR.PF is not modified by the addition of Pakunspecified.

        (Ruan et al., 2002)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Enhancer of
        Statement
        Reference

        Pakunspecified is a non-enhancer of abnormal neuroanatomy phenotype of Scer\GAL4GMR.PF, msnEP549

        (Ruan et al., 2002)
        NOT Suppressor of
        Statement
        Reference

        Pakunspecified is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4GMR.PF, msnEP549

        (Ruan et al., 2002)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        Pakunspecified is an enhancer | maternal effect of embryonic myoblast phenotype of Pak3del

        (Duan et al., 2012)
        NOT Enhancer of
        Statement
        Reference

        Pakunspecified is a non-enhancer of photoreceptor cell & axon phenotype of Scer\GAL4GMR.PF, msnEP549

        (Ruan et al., 2002)
        NOT Suppressor of
        Statement
        Reference

        Pakunspecified is a non-suppressor of photoreceptor cell & axon phenotype of Scer\GAL4GMR.PF, msnEP549

        (Ruan et al., 2002)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Pakunspecified Pak3del double zygotic embryos show a similar myoblast fusion defect to that of Pak3del single zygotic embryos. Embryos both maternally and zygotically mutant for both Pakunspecified and Pak3del show a complete lack of myoblast fusion. Embryos maternally mutant for Pakunspecified and both maternally and zygotically mutant for Pak3del show an intermediate myoblast fusion defect between that of the double maternal+zygotic mutants and the double zygotic mutants.

        Embryos that are maternally mutant for Pak3del and both maternally and zygotically mutant for Pakunspecified show a minor myoblast fusion defect.

        (Duan et al., 2012)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Pakunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (6)