FlyBase Allele Report: Dmel\cora[14]

General Information

Symbol

Dmel\cora¹⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0097018

Feature type

allele

Associated gene

Dmel\cora

Associated Insertion(s)

Carried in Construct

Also Known As

cor¹⁴

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lamb et al., 1998)

Progenitor genotype

Cytology

Description

Amino acid replacement: R1607term.

(Ward et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:19,242,758..19,242,758 [+]

Nucleotide change:

C19242758T

Amino acid change:

Reported amino acid change:

R1607term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Ward et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-231.UAS}

(Onur et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage

(Song et al., 2022)

abnormal neurophysiology | third instar larval stage

(Song et al., 2022)

lethal - all die before end of larval stage | recessive

(Lamb et al., 1998)

some die during larval stage | recessive

(Lamb et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

cora¹⁴ mutants show supernumerary boutons in the third instar larval neuromuscular junction; ventral longitudinal muscles exhibit increased evoked EJC amplitude and increased spontaneous EJC frequency.

(Song et al., 2022)

Mutant embryos show defects in tracheal barrier function at early stage 17 (dextran leaks into the tracheal lumen after injection into the hemolymph).

(Shaik et al., 2012)

Adult escapers are produced. cora⁸/cora¹⁴ adults have eye defects; part of the anterior equatorial region of the eye is replaced by head cuticle and associated bristles, and in other parts of the eye the ommatidia are irregular in size and shape and bristles are misplaced.

(Lamb et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

cora¹⁴ is a suppressor of visible | dominant phenotype of Egfr^E1

(Lamb et al., 1998)

Phenotype Manifest In

Suppressor of

Statement

Reference

cora¹⁴ is a suppressor of eye phenotype of Egfr^E1

(Lamb et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Dominantly suppresses the rough eye phenotype of Egfr^E1/+ heterozygotes; the eye is smaller than wild type with some roughening.

(Lamb et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

cora²

(Lamb et al., 1998)

Fails to complement

cora¹

(Lamb et al., 1998)

Rescued by

cora¹⁴ is rescued by cora^1.Ubi-p63E

(Lamb et al., 1998)

Partially rescued by

cora¹⁴ is partially rescued by cora^{1-1698.UAS.Tag:MYC}/Scer\GAL4^T80

(Ward et al., 2001)

Not rescued by

cora¹⁴ is not rescued by cora^{1-383.UAS.Tag:MYC}/Scer\GAL4^T80

(Ward et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9099

P{neoFRT}43D cora¹⁴/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

cor¹⁴

(Ward et al., 2001, Lamb et al., 1998)

cora14

(Khadilkar et al., 2017)

cora¹⁴

(Song et al., 2022, Rudrapatna et al., 2014, Shaik et al., 2012, Bahri et al., 2010, Bogdanik et al., 2008, Tonning et al., 2005)

cora^LOF

(Onur et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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