FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Taf1S-625
Open Close
General Information
Symbol
Dmel\Taf1S-625
Species
D. melanogaster
Name
FlyBase ID
FBal0095610
Feature type
allele
Associated gene
Dmel\Taf1
Associated Insertion(s)
Carried in Construct
Also Known As
SR3-5S-625
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: R1096P.

    (Wassarman et al., 2000)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:6,651,014..6,651,014 [+]
    Nucleotide change:

    G6651014C

    Amino acid change:

    R1093P | Taf1-PA; R1093P | Taf1-PB; R1093P | Taf1-PC; R1093P | Taf1-PD; R1136P | Taf1-PE; R1093P | Taf1-PF

    Reported amino acid change:

    R1096P

    Comment:

    Position of mutation on reference sequence inferred by FlyBase curator based on author statement (Figure 4: MDKFSRGN changes to MDKFSPGN).

    (Wassarman et al., 2000)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Taf1EP421/Taf1S-625 flies are have reduced bristle numbers on both male and female heads and are female sterile. Taf1EP421/Taf1S-625 mothers appear normal in size but eggs laid do not develop. Approximately 5% of egg chambers contain 8 instead of 16 cells.

        (Wassarman et al., 2000)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        Taf1S-625 is a suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC

        (Maixner et al., 1998)
        Other
        Phenotype Manifest In
        Enhancer of
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        When Taf1S-625 is added to dlunspecified/+ sensitized embryos they exhibit a dorsalised and twisted body pattern.

        (Pham and Sauer, 2000)

        The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by Taf1S-625.

        (Maixner et al., 1998)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Alleles of Taf1 form an allelic series based on phenotypic strength: Taf1XS-2232/Taf1EP421 > Taf1S-136/Taf1EP421 > Taf1S-625/Taf1EP421 > Taf1EP421/Taf1EP421.

        (Wassarman et al., 2000)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        SR3-5S-625
        (Wassarman et al., 2000, Maixner et al., 1998)
        Taf1S-625
        Taf250S-625
        (Pham and Sauer, 2000)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)