FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wg-C.UAS
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General Information
Symbol
Dmel\wg-C.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0095144
Feature type
allele
Associated gene
Dmel\wg
Associated Insertion(s)
Carried in Construct
P{UAS-wg.-C}
Also Known As
UAS-wgΔc
Key Links
Transgenic product class
dominant_negative_variant
(Klein and Martinez Arias, 1999)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Klein and Martinez Arias, 1999)
Mutagen
in vitro construct
(Klein and Martinez Arias, 1999)
Progenitor genotype
Carried in construct
P{UAS-wg.-C}
Cytology
Description

A dominant negative form of wg (with a stop codon at codon 398) is expressed under the control of UAS regulatory sequences.

(Klein and Martinez Arias, 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
wg
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      wg-C.Scer\UAS; Scer\GAL4ptc-559.1 embryos exhibit normal D-V elongation of the leading edge cells during dorsal closure, but the actin cable in leading edge cells is broken and patchy.

      (Kaltschmidt et al., 2002)

      Expression of wg-C.Scer\UAS under the control of Scer\GAL4sd-SG29.1 results in reduction of the wing pouch.

      (Klein and Martinez Arias, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The transformation of the legs and antenna seen in flies expressing vgScer\UAS.cZa under the control of Scer\GAL4Dll-md23 is strongly reduced by coexpression of wg-C.Scer\UAS.

      (Baena-Lopez and Garcia-Bellido, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      wg-C.Scer\UAS
      wg-C.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (6)