FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sggS9A.UAS
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General Information
Symbol
Dmel\sggS9A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0092527
Feature type
allele
Associated gene
Dmel\sgg
Associated Insertion(s)
Carried in Construct
P{UAS-sgg.S9A}
Also Known As
UAS-SggS9A, UAS-sggact, UAS-sggS9A, UAS-sgg, sggS9A, SGGACTIVE, UAS-sgg(S9A), UAS-sggCA
Key Links
Transgenic product class
missense_variant
(Hazelett et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Hazelett et al., 1998)
Mutagen
in vitro construct
(Hazelett et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-sgg.S9A}
Cytology
Description

UASt regulatory sequences drive expression of a cDNA fragment encoding a constitutively active form of sgg (carries the amino acid replacement S9A).

(Hazelett et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
sgg
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Alzheimer's disease
      CEA
      (Ataellahi et al., 2023)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Huntington's disease
      modeled by Hsap\HTTQ93.ex1.UAS
      (Dupont et al., 2012)
      ameliorates  cancer
      modeled by Ras85DV12.UAS
      (Waghmare et al., 2024)
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cAa
      (Mudher et al., 2004)
      modeled by Hsap\MAPTUAS.2N4R
      (Povellato et al., 2014)
      ameliorates  tauopathy
      modeled by Hsap\MAPTUAS.cAa
      (Cowan et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      adult hemolymph | nutrition conditional, with Scer\GAL4hs.PB

      (Lee et al., 2024)

      adult thorax & chaeta, with Scer\GAL4sca-537.4

      (Bourouis, 2002)

      axon | third instar larval stage, with Scer\GAL4Appl.G1a

      (Banerjee et al., 2018)

      bouton | larval stage, with Scer\GAL4elav.PU

      (Gogel et al., 2006)

      dorsocentral bristle, with Scer\GAL4C-765

      (Yang et al., 2012)

      embryonic/larval crystal cell, with Scer\GAL4He.PZ

      (Zettervall et al., 2004)

      eye, with Scer\GAL4dve.PU

      (Puli et al., 2024)

      eye-antennal disc | larval stage, with Scer\GAL4dve.PU

      (Puli et al., 2024)

      eye disc | ectopic | larval stage, with Scer\GAL4dve.PU

      (Puli et al., 2024)

      eye disc morphogenetic furrow, with Scer\GAL4dpp.blk1

      (Kumar and Moses, 2001)

      female germline stem cell, with Scer\GAL4bab1-Gal4

      (Lin et al., 2020)

      germarium, with Scer\GAL4bab1-Gal4

      (Lin et al., 2020)

      lamellocyte, with Scer\GAL4He.PZ

      (Zettervall et al., 2004)

      larval segmental nerve | third instar larval stage, with Scer\GAL4Appl.G1a

      (Banerjee et al., 2018)

      mechanosensory neuron of leg campaniform sensillum | increased number | nutrition conditional, with Scer\GAL4VGlut1-OK371

      (Lee et al., 2024)

      melanotic mass, with Scer\GAL4He.PZ

      (Zettervall et al., 2004)

      mesonotum, with Scer\GAL4455.2

      (Bourouis, 2002)

      mesonotum | ectopic, with Scer\GAL4vg.PM

      (Bourouis, 2002)

      ommatidium, with Scer\GAL4GMR.PF

      (Povellato et al., 2014)

      posterior dorsocentral bristle, with Scer\GAL4C-765

      (Yang et al., 2012)

      scutellum, with Scer\GAL4455.2

      (Bourouis, 2002)

      wing, with Scer\GAL4sca-537.4

      (Bourouis, 2002)

      wing, with Scer\GAL4vg.PM

      (Bourouis, 2002, Collins and Treisman, 2000)

      wing margin, with Scer\GAL4vg.PM

      (Collins and Treisman, 2000)

      wing margin bristle, with Scer\GAL4sca-537.4

      (Bourouis, 2002)
      Detailed Description
      Statement
      Reference

      Expression of sggS9A.UAS under the control of Scer\GAL4Appl.G1a leads to axonal blockages in third instar larval segmental nerves compared to controls.

      (Banerjee et al., 2018)

      Expression of Scer\GAL4GMR.PF>sggS9A.Scer\UAS causes mild disruption of ommatidia.

      (Povellato et al., 2014)

      Third instar larvae expressing sggS9A.Scer\UAS under the control of Scer\GAL4elav-C155 crawl more slowly and switch direction more frequently compared to wild-type.

      (Jakubowski et al., 2012)

      Nearly 20% of flies expressing sggS9A.Scer\UAS under the control of Scer\GAL4C-765 lack all dorsocentral bristles and the remainder have a single tiny posterior dorsocentral bristle which is 46% shorter than normal.

      (Yang et al., 2012)

      Overexpression of sggS9A.Scer\UAS in clock cells under the control of Scer\GAL4tim.PE results in a shortening of circadian period.

      Overexpression of sggS9A.Scer\UAS in post-mitotic neurons under the control of Scer\GAL4elav-C155 results in increased olfactory habituation.

      (Wolf et al., 2007)

      There is a decrease in the number of synaptic boutons at the neuromuscular junction in larvae expressing sggS9A.Scer\UAS under the control of Scer\GAL4elav.PU.

      (Gogel et al., 2006)

      Expression of sggS9A.Scer\UAS under the control of Scer\GAL4ey.PH does not affect eye size.

      (Singh et al., 2006)

      When expression is driven by Scer\GAL4He.PZ, hemocyte proliferation is unaffected, lamellocyte numbers are increased (with low penetrance) and crystal cells are unaffected. Melanotic masses form.

      (Zettervall et al., 2004)

      Expression of sggS9A.Scer\UAS under the control of Scer\GAL4vg.PM results in wing defects such as nicking of the wing, a miniature wing phenotype and wing to notum transformations. Expression of sggS9A.Scer\UAS under the control of Scer\GAL4455.2 results in a reduced scutellum and variable cleft notum phenotype. Expression of sggS9A.Scer\UAS under the control of Scer\GAL4sca-537.4 results in sparse wing margin bristles and some notching of the wing and loss or tiny thoracic chaetae.

      (Bourouis, 2002)

      Expression of sggS9A.Scer\UAS in clones under the control of Scer\GAL4Act5C.PI does not suppress eye development.

      (Singh et al., 2002)

      Expression of sggS9A.Scer\UAS under the control of Scer\GAL4dpp.blk1 activates furrow reincarnation in the eye disc.

      (Kumar and Moses, 2001)

      When sggS9A.Scer\UAS is expressed under the control of Scer\GAL4vg.PM, a reduction in wing growth and the loss of the wing margin is seen.

      (Collins and Treisman, 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Statement
      Reference

      Scer\GAL4vg.PM, sggS9A.UAS has wing margin phenotype, non-enhanceable by ash21

      (Collins and Treisman, 2000)

      Scer\GAL4vg.PM, sggS9A.UAS has wing phenotype, non-enhanceable by ash21

      (Collins and Treisman, 2000)
      Suppressed by
      Statement
      Reference

      Scer\GAL4Appl.G1a, sggS9A.UAS has larval segmental nerve | third instar larval stage phenotype, suppressible by Hsap\PSEN1loopA.UAS, Scer\GAL4Appl.G1a

      (Banerjee et al., 2018)

      Scer\GAL4Appl.G1a, sggS9A.UAS has axon | third instar larval stage phenotype, suppressible by Hsap\PSEN1loopA.UAS, Scer\GAL4Appl.G1a

      (Banerjee et al., 2018)

      Scer\GAL4Appl.G1a, sggS9A.UAS has larval segmental nerve | third instar larval stage phenotype, suppressible by Psn+14.UAS, Scer\GAL4Appl.G1a

      (Banerjee et al., 2018)

      Scer\GAL4Appl.G1a, sggS9A.UAS has axon | third instar larval stage phenotype, suppressible by Psn+14.UAS, Scer\GAL4Appl.G1a

      (Banerjee et al., 2018)

      Scer\GAL4Appl.G1a, sggS9A.UAS has larval segmental nerve | third instar larval stage phenotype, suppressible by Psn-14.UAS, Scer\GAL4Appl.G1a

      (Banerjee et al., 2018)

      Scer\GAL4Appl.G1a, sggS9A.UAS has axon | third instar larval stage phenotype, suppressible by Psn-14.UAS, Scer\GAL4Appl.G1a

      (Banerjee et al., 2018)

      Scer\GAL4Appl.G1a, sggS9A.UAS has larval segmental nerve | third instar larval stage phenotype, suppressible by PsnUAS.loop.Tag:MYC, Scer\GAL4Appl.G1a

      (Banerjee et al., 2018)

      Scer\GAL4Appl.G1a, sggS9A.UAS has axon | third instar larval stage phenotype, suppressible by PsnUAS.loop.Tag:MYC, Scer\GAL4Appl.G1a

      (Banerjee et al., 2018)

      Scer\GAL4vg.PM, sggS9A.UAS has wing phenotype, suppressible by mor1

      (Collins and Treisman, 2000)

      Scer\GAL4vg.PM, sggS9A.UAS has wing phenotype, suppressible by osa308

      (Collins and Treisman, 2000)

      Scer\GAL4vg.PM, sggS9A.UAS has wing margin phenotype, suppressible by AxnE77

      (Collins and Treisman, 2000)

      Scer\GAL4vg.PM, sggS9A.UAS has wing margin phenotype, suppressible by brmT362

      (Collins and Treisman, 2000)

      Scer\GAL4vg.PM, sggS9A.UAS has wing margin phenotype, suppressible by mor1

      (Collins and Treisman, 2000)

      Scer\GAL4vg.PM, sggS9A.UAS has wing margin phenotype, suppressible by osa308

      (Collins and Treisman, 2000)

      Scer\GAL4vg.PM, sggS9A.UAS has wing phenotype, suppressible by AxnE77

      (Collins and Treisman, 2000)

      Scer\GAL4vg.PM, sggS9A.UAS has wing phenotype, suppressible by brmT362

      (Collins and Treisman, 2000)
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4vg.PM, sggS9A.UAS has wing margin phenotype, non-suppressible by ash21

      (Collins and Treisman, 2000)

      Scer\GAL4vg.PM, sggS9A.UAS has wing phenotype, non-suppressible by ash21

      (Collins and Treisman, 2000)
      Enhancer of
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of sggS9A.Scer\UAS does not suppress the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

      (Wong et al., 2013)

      Co-expression of sggS9A.Scer\UAS and MadScer\UAS.cNa under the control of Scer\GAL4sca-537.4 results in wings with no L1 or L3 sensilla, missing margin bristles of all types and occasional vein truncations.

      (Quijano et al., 2011)

      Expression of sggS9A.Scer\UAS under the control of Scer\GAL4ey.PH provides a partial rescue of the ventral eye loss phenotype of L2/+ flies; the suppression is significant in 26% of flies and is weak in the remaining flies.

      Expression of either sggS9A.Scer\UAS, under the control of Scer\GAL4ey.PH, in Lrev6-3 clones suppresses the loss of ventral cells in the eye disc.

      (Singh et al., 2006)

      Coexpression of both sggS9A.Scer\UAS and tshScer\UAS.cGa under the control of Scer\GAL4ey.PH does not suppress eye development. Coexpression of both sggS9A.Scer\UAS and tshScer\UAS.cGa in clones under the control of Scer\GAL4Act5C.PI does not suppress eye development either in the ventral or dorsal margin of the eye. Coexpression of both sggS9A.Scer\UAS and tshScer\UAS.cGa under the control of Scer\GAL4dpp.blk1 does not suppress eye development either in the ventral or dorsal margin of the eye.

      (Singh et al., 2002)

      eyg1/Df(3L)iro-2 hemizygous eye discs completely lack photoreceptors. Photoreceptor development in these discs is rescued by sggS9A.Scer\UAS expressed under the control of Scer\GAL4dpp.PH. The lack of photoreceptor phenotype of eya1 eye discs is not rescued by sggS9A.Scer\UAS expressed under the control of Scer\GAL4ey.PH.

      (Hazelett et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of sggS9A.Scer\UAS and Hsap\MAPTScer\UAS.2N4R under the control of Scer\GAL4GMR.PF results in increased eye disruption relative to the expression of each transgene alone. The ommatidia are more severely disrupted and patches of pigment loss and glazing are visible in the eyes of the mutants.

      (Povellato et al., 2014)

      Co-expression of sggS9A.Scer\UAS does not affect Syt1 aggregation in motor axons in the NMJ of Scer\GAL4elav.PU>Hsap\APP695.Scer\UAS.T:Hsap\MYC third instar larvae.

      (Shaw and Chang, 2013)

      Co-expression of sggS9A.Scer\UAS leads to lethality in flies with expression of Hsap\HTTQ93.ex1p.Scer\UAS driven by Scer\GAL4elav.PU.

      (Dupont et al., 2012)

      Co-expression of sggS9A.Scer\UAS with Hsap\MAPTScer\UAS.cAa under the control of Scer\GAL4D42 exacerbates the locomotor dysfunction seen when Hsap\MAPTScer\UAS.cAa alone is expressed in larvae.

      (Mudher et al., 2004)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (4)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      SGGACTIVE
      (Banerjee et al., 2018)
      sggACTIVE
      (Banerjee et al., 2021)
      sggS9A.Scer\UAS
      sggS9A.UAS
      sggS9A
      (Dupont et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (42)