FlyBase Allele Report: Dmel\Mef2[424]

General Information

Symbol

Dmel\Mef2⁴²⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0044933

Feature type

allele

Associated gene

Dmel\Mef2

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Mantrova et al., 1999, Ranganayakulu et al., 1995)

Mutagen

ethyl methanesulfonate

(Ranganayakulu et al., 1995)

Progenitor genotype

Cytology

Description

Amino acid replacement: S186P. Nucleotide substitution: T?C.

(Ranganayakulu et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:9,919,450..9,919,450 [-]

Nucleotide change:

T9919450C

Reported nucleotide change:

T?C

Amino acid change:

Reported amino acid change:

S186P

(Ranganayakulu et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Mantrova et al., 1999)

lethal - all die during embryonic stage | recessive

(Ranganayakulu et al., 1995)

partially lethal

(Mantrova et al., 1999)

some die during embryonic stage | recessive

(Ranganayakulu et al., 1995)

Phenotype Manifest In

centripetal follicle cell

(Mantrova et al., 1999)

dorsal appendage

(Mantrova et al., 1999)

egg

(Mantrova et al., 1999)

larval somatic muscle cell

(Ranganayakulu et al., 1995)

Detailed Description

Statement

Reference

Mef2⁶⁵/Mef2⁴²⁴ adults survive at 20-30% rate of sibling classes. Eggs laid by Mef2⁶⁵/Mef2⁴²⁴ females show 36.9% wild type dorsal appendages, 24.2% reduced dorsal appendages, 19.9% broad dorsal appendages and short egg length, 8.5% broad dorsal appendages and normal egg length, 6.9% abnormal dorsal appendages with short egg length and 3-6% cup-like eggs with no dorsal appendages and cup-like shape. At stage 10 of oogenesis in Mef2⁶⁵/Mef2⁴²⁴ females the centripetally migrating follicle cells become ill defined. Instead of forming a straight line they advance too much posteriorly, lag behind or lose their identities completely. Eggs laid by Mef2⁴²⁴/+ show 92.6% wild type dorsal appendages, 6.8% reduced dorsal appendages, 0.3% broad dorsal appendages and short egg length and 0.3% abnormal dorsal appendages with short egg length.

(Mantrova et al., 1999)

In homozygous mutant embryos, certain individual muscles of the segmentally repeated pattern are absent. Specification of myoblasts is apparently normal.

(Ranganayakulu et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

Mef2⁴²⁴, sax¹ has egg phenotype

(Mantrova et al., 1999)

Mef2⁴²⁴, sax¹ has dorsal appendage phenotype

(Mantrova et al., 1999)

Mef2⁴²⁴, tkv⁷ has egg phenotype

(Mantrova et al., 1999)

Mef2⁴²⁴, tkv⁷ has dorsal appendage phenotype

(Mantrova et al., 1999)

Mef2⁴²⁴, dpp^hr56 has egg phenotype

(Mantrova et al., 1999)

Mef2⁴²⁴, dpp^hr56 has dorsal appendage phenotype

(Mantrova et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Eggs laid by Mef2⁴²⁴/tkv⁷ females show 48.3% wild type dorsal appendages, 11.6% reduced dorsal appendages, 21.5% broad dorsal appendages and short egg length, 2.9% broad dorsal appendages and normal egg length, 12.2% abnormal dorsal appendages with short egg length and 1.2% cup-like eggs with no dorsal appendages and cup-like shape. Eggs laid by Mef2⁴²⁴/sax¹ females show 88.3% wild type dorsal appendages, 10.0% reduced dorsal appendages, 1.2% broad dorsal appendages and short egg length, 0.2% broad dorsal appendages and normal egg length, and 0.2% abnormal dorsal appendages with short egg length. Eggs laid by Mef2⁴²⁴/dpp^hr56 females show 92.3% wild type dorsal appendages, 0.9% reduced dorsal appendages, 3.0% broad dorsal appendages and short egg length, 0.4% broad dorsal appendages and normal egg length and 2.8% abnormal dorsal appendages with short egg length.

(Mantrova et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

D-mef2⁴²⁴

(Mantrova et al., 1999)

Dmef2⁴²⁴

(Wong et al., 2008)

Mef2⁴²⁴

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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