FlyBase Allele Report: Dmel\ph-p[2]

General Information

Symbol

Dmel\ph-p²

Species

D. melanogaster

Name

FlyBase ID

FBal0039750

Feature type

allele

Associated gene

Dmel\ph-p

Associated Insertion(s)

Carried in Construct

Also Known As

ph²

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

PM hybrid dysgenesis

Nature of the Allele

Allele class

Mutagen

PM hybrid dysgenesis

(Saget and Randsholt, 1994, Dura et al., 1987)

Progenitor genotype

Caused by aberration

Df(1)ph-2

Cytology

Description

Deletion of approximately 10kb that joins the 5' end (promoter, untranslated leader and 5' coding sequences) of ph-p to the 3' end of ph-d (3' coding region and untranslated sequences) and removes all sequences in between.

(Saget and Randsholt, 1994)

Deletion of some of ph-d and some of ph-p.

(Dura et al., 1987)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:2,128,823..2,130,069 [-]

Comment:

ph-p² is a 10kb deletion that removes the 3' end of ph-p and the 5' end of ph-d. The breakpoint maps within a 1247bp region that is identicle between the two genes but cannot be further localized.

(Saget and Randsholt, 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive | heat sensitive

(Cheng et al., 1994)

Phenotype Manifest In

abdominal segment 1

(Saget and Randsholt, 1994)

abdominal segment 4

(Saget and Randsholt, 1994)

mesothoracic leg

(Saget and Randsholt, 1994)

metathoracic leg

(Saget and Randsholt, 1994)

postpronotum

(Saget and Randsholt, 1994)

sex comb

(Wang and Brock, 2003)

wing blade posterior compartment

(Saget and Randsholt, 1994)

Detailed Description

Statement

Reference

ph-p²/+ heterozygous mutant flies exhibit a higher than wild-type average number of legs with sex combs, with an average of 2.6 legs with sex combs, compared to 2.0 in wild-type, although this is not statistically significant.

(Wang and Brock, 2003)

Heterozygotes with Psc¹ are lethal.

(Cheng et al., 1994)

Hemizygous males usually have sex combs on the second and third legs, show a partial transformation of the posterior wing compartment towards the haltere and show a partial transformation of abdominal segment A4 towards A5, at both 25 and 29^oC. Hemizygous males rarely show loss of the humerus and occasionally show partial transformation of abdominal segment A1 towards A2 at 25^oC. At 29^oC, both these phenotypes are more common. The expressivity and penetrance of these homeotic transformation phenotypes are comparable in ph-p² and ph-p⁴ males.

(Saget and Randsholt, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

en⁴, ph-d², ph-p² has visible | dominant phenotype

(Maschat et al., 1998)

en⁵⁴, ph-d², ph-p² has visible | dominant phenotype

(Maschat et al., 1998)

en⁵⁴, ph-d², ph-p² has visible phenotype

(Maschat et al., 1998)

en⁴, ph-d², ph-p² has visible phenotype

(Maschat et al., 1998)

Df(2L)Prl, ph-p² has lethal phenotype

(Landecker et al., 1994)

Phenotype Manifest In

Enhanced by

Statement

Reference

ph-p² has sex comb phenotype, enhanceable by Hsc70-4¹⁹⁵/Hsc70-4[+]

(Wang and Brock, 2003)

ph-p² has leg phenotype, enhanceable by Df(2L)esc-P2-0

(Landecker et al., 1994)

ph-p² has sex comb phenotype, enhanceable by Df(2L)esc-P2-0

(Landecker et al., 1994)

ph-p² has leg phenotype, enhanceable by Df(2L)TW3

(Landecker et al., 1994)

ph-p² has sex comb phenotype, enhanceable by Df(2L)TW3

(Landecker et al., 1994)

ph-p² has leg phenotype, enhanceable by Df(2L)TW201

(Landecker et al., 1994)

ph-p² has sex comb phenotype, enhanceable by Df(2L)TW201

(Landecker et al., 1994)

ph-p² has leg phenotype, enhanceable by Df(2R)CA53

(Landecker et al., 1994)

ph-p² has sex comb phenotype, enhanceable by Df(2R)CA53

(Landecker et al., 1994)

ph-p² has leg phenotype, enhanceable by Df(2R)cn83c

(Landecker et al., 1994)

ph-p² has sex comb phenotype, enhanceable by Df(2R)cn83c

(Landecker et al., 1994)

ph-p² has leg phenotype, enhanceable by Df(3L)fz-GF3b

(Landecker et al., 1994)

ph-p² has sex comb phenotype, enhanceable by Df(3L)fz-GF3b

(Landecker et al., 1994)

ph-p² has leg phenotype, enhanceable by Df(2L)prd1.7

(Landecker et al., 1994)

ph-p² has leg phenotype, enhanceable by Df(3L)fz-GS1a

(Landecker et al., 1994)

ph-p² has sex comb phenotype, enhanceable by Df(3L)fz-GS1a

(Landecker et al., 1994)

ph-p² has leg phenotype, enhanceable by Df(3L)fz-CAL5

(Landecker et al., 1994)

ph-p² has sex comb phenotype, enhanceable by Df(3L)fz-CAL5

(Landecker et al., 1994)

ph-p² has sex comb phenotype, enhanceable by Df(2L)prd1.7

(Landecker et al., 1994)

ph-p² has leg phenotype, enhanceable by Df(2L)esc10

(Landecker et al., 1994)

ph-p² has sex comb phenotype, enhanceable by Df(2L)esc10

(Landecker et al., 1994)

ph-p² has leg phenotype, enhanceable by salm¹

(Landecker et al., 1994)

ph-p² has sex comb phenotype, enhanceable by salm¹

(Landecker et al., 1994)

ph-p² has leg phenotype, enhanceable by Df(2L)H20

(Landecker et al., 1994)

ph-p² has sex comb phenotype, enhanceable by Df(2L)H20

(Landecker et al., 1994)

Suppressed by

Statement

Reference

ph-p² has phenotype, suppressible by ph-d^+tSa

(Saget and Randsholt, 1994)

Other

Statement

Reference

en⁴, ph-d², ph-p² has wing vein L4 phenotype

(Maschat et al., 1998)

en⁵⁴, ph-d², ph-p² has wing vein L4 phenotype

(Maschat et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

ph-p²/Hsc70-4¹⁹⁵ mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 4.0 legs with sex combs, compared to 2.6 in ph-p²/+ heterozygotes.

(Wang and Brock, 2003)

ph-d² ph-p² homozygotes do not show a gap in the fourth wing vein at 25 or 29^oC. 100% of ph-d² ph-p²/+ ; en⁵⁴/+ flies have a gap in the fourth wing vein at 29^oC. 100% of ph-d² ph-p²/+ ; en⁴/+ flies have a gap in the fourth wing vein at 29^oC.

(Maschat et al., 1998)

The extra sex combs phenotype of ph-p² heterozygotes is dominantly enhanced by Df(2L)esc-P2-0, Df(2L)prd1.7, Df(2L)esc10, salm¹, Df(2L)H20, Df(2L)TW3, Df(2L)TW201, Df(2R)CA53, Df(2R)cn83c, Df(3L)fz-GF3b, Df(3L)fz-GS1a and Df(3L)fz-CAL5. Lethal in heterozygous combination with Df(2L)Prl.

(Landecker et al., 1994)

Males are completely rescued by ph-d^+tSa.

(Saget and Randsholt, 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ph-p²

ph²

(Wang and Brock, 2003, Maschat et al., 1998, Campbell et al., 1995, Saget and Randsholt, 1994)

Name Synonyms

Secondary FlyBase IDs

References (7)

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