FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\E(z)son3
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General Information
Symbol
Dmel\E(z)son3
Species
D. melanogaster
Name
suppressor of nanos 3
FlyBase ID
FBal0038833
Feature type
allele
Associated gene
Dmel\E(z)
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Pelegri and Lehmann, 1994)
Mutagen
ethyl methanesulfonate
(Pelegri and Lehmann, 1994)
Progenitor genotype
Cytology
Description

Amino acid replacement: I635N.

(Joshi et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:10,635,017..10,635,017 [-]
Nucleotide change:

T10635017A

Amino acid change:

I635N | E(z)-PA; I635N | E(z)-PB; I640N | E(z)-PC

Reported amino acid change:

I635N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Joshi et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      E(z)son3 strongly suppresses the trx-like phenotype (transformation of T1 to T2, T3 to T2 and A5 to A4) seen in E(z)Trm heterozygotes; phenotype is nearly wild-type.

      (Bajusz et al., 2001)

      Lethal when transheterozygous with E(z)son1 and E(z)son2. Lethal in trans to E(z) null alleles or deficiencies.

      (Pelegri and Lehmann, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      E(z)son3 is a suppressor of phenotype of nanosunspecified

      (Pelegri and Lehmann, 1994)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Strong suppressor of the z-w interaction. E(z)son3/+ shows 13% suppression of the nos abdominal phenotype. E(z)son1/E(z)son3 or E(z)son2/E(z)son3 shows 100% suppression of the nos abdominal phenotype, when the E(z)son3 allele is contributed from a germ line clone.

      (Pelegri and Lehmann, 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      E(z)son3
      (Lv et al., 2018, Joshi et al., 2008)
      Name Synonyms
      suppressor of nanos 3
      (Pelegri and Lehmann, 1994)
      Secondary FlyBase IDs
        References (5)