FlyBase Allele Report: Dmel\Pcl[12]

General Information

Symbol

Dmel\Pcl¹²

Species

D. melanogaster

Name

FlyBase ID

FBal0013619

Feature type

allele

Associated gene

Dmel\Pcl

Associated Insertion(s)

Carried in Construct

Also Known As

Pcl^w6

Key Links

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(McKeon and Brock, 1991)

loss of function allele

(Cheng et al., 1994)

Mutagen

gamma ray

(Lindsley and Zimm, 1992)

Progenitor genotype

Cytology

Description

Point mutation.

(McKeon and Brock, 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic midgut constriction

(McKeon and Brock, 1991)

mesothoracic leg

(Lindsley and Zimm, 1992)

metathoracic leg

(Lindsley and Zimm, 1992)

Detailed Description

Statement

Reference

Embryonic lethal or semi-lethal when heterozygous with ph-d². Unhatched larvae carry segmentation defects or polarity defects.

(McKeon et al., 1994)

Transformation of legs 2 and 3 to leg 1.

(Lindsley and Zimm, 1992)

Lack midgut constrictions.

(McKeon and Brock, 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

E(Pc)^unspecified, Pcl¹² has visible | homeotic phenotype

(Sato and Denell, 1985)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pcl¹² has leg phenotype, enhanceable by Df(2R)trix

(Landecker et al., 1994)

Pcl¹² has sex comb phenotype, enhanceable by Df(2R)trix

(Landecker et al., 1994)

Pcl¹² has leg phenotype, enhanceable by Df(3L)fz-GF3b

(Landecker et al., 1994)

Pcl¹² has sex comb phenotype, enhanceable by Df(3L)fz-GF3b

(Landecker et al., 1994)

Pcl¹² has leg phenotype, enhanceable by Df(3L)Pc

(Landecker et al., 1994)

Pcl¹² has sex comb phenotype, enhanceable by Df(3L)Pc

(Landecker et al., 1994)

Pcl¹² has leg phenotype, enhanceable by Df(2L)H20

(Landecker et al., 1994)

Pcl¹² has sex comb phenotype, enhanceable by Df(2L)H20

(Landecker et al., 1994)

Pcl¹² has leg phenotype, enhanceable by Df(2L)TW3

(Landecker et al., 1994)

Pcl¹² has sex comb phenotype, enhanceable by Df(2L)TW3

(Landecker et al., 1994)

Pcl¹² has leg phenotype, enhanceable by Df(2R)CA53

(Landecker et al., 1994)

Pcl¹² has sex comb phenotype, enhanceable by Df(2R)CA53

(Landecker et al., 1994)

Pcl¹² has phenotype, enhanceable by E(Pc)¹

(Lindsley and Zimm, 1992)

Other

Statement

Reference

E(Pc)^unspecified, Pcl¹² has mesothoracic segment | dorsal phenotype

(Sato and Denell, 1985)

Additional Comments

Genetic Interactions

Statement

Reference

The extra sex combs phenotype of Pcl¹² heterozygotes is dominantly enhanced by Df(2R)trix, Df(3L)Pc, Df(2L)H20, Df(2L)TW3, Df(2R)CA53 and Df(3L)fz-GF3b.

(Landecker et al., 1994)

E(Pc)^unspecified/Pcl¹² double homozygotes show some anterior transformation of the dorsal mesothorax, having a dorsal strip of naked cuticle.

(Sato and Denell, 1985)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Williams.

(Lindsley and Zimm, 1992)

Comments

The anterior transformation seen in E(Pc)^unspecified/Pcl¹² double homozygotes depends on Scr⁺ activity.

(Sato and Denell, 1985)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Pcl-W6

(Sinclair et al., 1998)

Pcl¹²

Pcl^W6

(Sato and Denell, 1985)

Pcl^w6

(McKeon and Brock, 1991)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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