FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CtBP87De-10
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General Information
Symbol
Dmel\CtBP87De-10
Species
D. melanogaster
Name
FlyBase ID
FBal0010480
Feature type
allele
Associated gene
Dmel\CtBP
Associated Insertion(s)
Carried in Construct
Also Known As
dCtBP87De-10, CtBPl(3)87De-10, CtBPDE10
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Zhang and Arnosti, 2011)
Mutagen
ethyl methanesulfonate
(Hilliker et al., 1981)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Bhambhani, 2007.11.5)

Amino acid replacement: Q229term.

(Bhambhani, 2007.11.5)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:13,021,037..13,021,037 [+]
Nucleotide change:

C13021037T

Reported nucleotide change:

C?T

Amino acid change:

Q229term | CtBP-PA; Q229term | CtBP-PB; Q229term | CtBP-PC; Q229term | CtBP-PD; Q229term | CtBP-PE; Q229term | CtBP-PF; Q229term | CtBP-PG; Q229term | CtBP-PH; Q229term | CtBP-PI; Q229term | CtBP-PJ

Reported amino acid change:

Q229term

(Bhambhani, 2007.11.5)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Schimke immuno-osseous dysplasia
      modeled by Marcal1UAS.cBa
      (Morimoto et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      abnormal cell polarity | cell autonomous | somatic clone

      (Stern et al., 2009)

      abnormal neuroanatomy | pharate adult stage (with CtBP03463)

      (Hoang et al., 2010)

      abnormal neuroanatomy | pharate adult stage (with Df(3R)ry615)

      (Hoang et al., 2010)

      abnormal neuroanatomy | somatic clone - Minute background | third instar larval stage

      (Hoang et al., 2010)

      abnormal size | adult stage | somatic clone - Minute background

      (Hoang et al., 2010)

      abnormal size | pharate adult stage (with CtBP03463)

      (Hoang et al., 2010)

      abnormal size | pharate adult stage (with Df(3R)ry615)

      (Hoang et al., 2010)

      abnormal size | somatic clone | third instar larval stage

      (Hoang et al., 2010)

      increased occurrence of cell division | somatic clone | third instar larval stage

      (Hoang et al., 2010)

      increased size | adult stage | somatic clone - tissue specific

      (Vissers et al., 2020)

      lethal

      (Stern et al., 2007, Hilliker et al., 1981)

      lethal - all die before end of larval stage

      (Hoang et al., 2010)

      lethal - all die before end of P-stage (with CtBP03463)

      (Hoang et al., 2010, Barolo et al., 2002)

      lethal - all die before end of P-stage (with Df(3R)ry615)

      (Hoang et al., 2010)

      partially lethal - majority live | somatic clone

      (Hoang et al., 2010)

      partially lethal - majority live | somatic clone - Minute background

      (Hoang et al., 2010)

      some die during pharate adult stage (with CtBP03463)

      (Barolo et al., 2002)

      visible | adult stage | somatic clone - Minute background

      (Hoang et al., 2010)

      visible | adult stage | somatic clone - tissue specific

      (Vissers et al., 2020)

      visible | dominant

      (Barolo et al., 2002)

      visible | pharate adult stage (with CtBP03463)

      (Hoang et al., 2010)

      visible | pharate adult stage (with Df(3R)ry615)

      (Hoang et al., 2010)
      Phenotype Manifest In

      adult cuticle | pharate adult stage (with CtBP03463)

      (Hoang et al., 2010)

      adult cuticle | somatic clone - Minute background

      (Hoang et al., 2010)

      adult head | somatic clone - tissue specific

      (Vissers et al., 2020)

      adult head bristle | somatic clone - Minute background

      (Hoang et al., 2010)

      antenna | somatic clone - Minute background

      (Hoang et al., 2010)

      antennal segment 2 microchaeta | pharate adult stage (with Df(3R)ry615)

      (Hoang et al., 2010)

      anterior dorsocentral bristle | adult stage | somatic clone

      (Stern et al., 2009)

      anterior dorsocentral bristle | adult stage | somatic clone | increased number

      (Stern et al., 2009)

      anterior notopleural bristle | adult stage | somatic clone

      (Stern et al., 2009)

      anterior notopleural bristle | adult stage | somatic clone | increased number

      (Stern et al., 2009)

      anterior postalar bristle | adult stage | somatic clone

      (Stern et al., 2009)

      anterior postalar bristle | adult stage | somatic clone | increased number

      (Stern et al., 2009)

      anterior postalar bristle | pharate adult stage | increased number (with CtBP03463)

      (Stern et al., 2009)

      anterior scutellar bristle | adult stage | somatic clone

      (Stern et al., 2009)

      anterior scutellar bristle | adult stage | somatic clone | increased number

      (Stern et al., 2009)

      anterior scutellar bristle | pharate adult stage (with CtBP03463)

      (Stern et al., 2009)

      anterior scutellar bristle | pharate adult stage | increased number (with CtBP03463)

      (Stern et al., 2009)

      anterior supraalar bristle | adult stage | somatic clone

      (Stern et al., 2009)

      anterior supraalar bristle | adult stage | somatic clone | increased number

      (Stern et al., 2009)

      arista | pharate adult stage (with Df(3R)ry615)

      (Hoang et al., 2010)

      cyst progenitor cell | somatic clone

      (Leatherman and DiNardo, 2008)

      eye | pharate adult stage (with CtBP03463)

      (Hoang et al., 2010)

      eye | pharate adult stage (with Df(3R)ry615)

      (Hoang et al., 2010)

      eye | somatic clone - Minute background

      (Hoang et al., 2010)

      eye | somatic clone - tissue specific

      (Vissers et al., 2020)

      eye disc | somatic clone - Minute background

      (Hoang et al., 2010)

      eye disc anterior to the morphogenetic furrow | somatic clone | third instar larval stage

      (Hoang et al., 2010)

      frontal bristle | pharate adult stage (with CtBP03463)

      (Hoang et al., 2010)

      frontal bristle | somatic clone - Minute background

      (Hoang et al., 2010)

      interocellar bristle | pharate adult stage (with CtBP03463)

      (Hoang et al., 2010)

      interocellar bristle | somatic clone - Minute background

      (Hoang et al., 2010)

      interommatidial bristle | pharate adult stage (with CtBP03463)

      (Hoang et al., 2010)

      macrochaeta

      (Barolo et al., 2002)

      macrochaeta (with CtBP03463)

      (Barolo et al., 2002)

      macrochaeta | increased number, with CtBPUbi.Tag:MYC

      (Stern et al., 2007)

      mesonotum | adult stage | somatic clone

      (Stern et al., 2009)

      mesonotum | pharate adult stage (with CtBP03463)

      (Stern et al., 2009)

      notal microchaeta | cell autonomous | somatic clone

      (Stern et al., 2009)

      ocellar bristle | somatic clone - Minute background

      (Hoang et al., 2010)

      ocellar triangle | pharate adult stage (with CtBP03463)

      (Hoang et al., 2010)

      ocellar triangle | somatic clone - Minute background

      (Hoang et al., 2010)

      ocellus | pharate adult stage (with CtBP03463)

      (Hoang et al., 2010)

      ocellus | somatic clone - Minute background

      (Hoang et al., 2010)

      ommatidium | pharate adult stage | increased number (with CtBP03463)

      (Hoang et al., 2010)

      ommatidium | pharate adult stage | increased number (with Df(3R)ry615)

      (Hoang et al., 2010)

      orbital bristle | pharate adult stage | increased number (with CtBP03463)

      (Hoang et al., 2010)

      orbital bristle | somatic clone - Minute background

      (Hoang et al., 2010)

      posterior dorsocentral bristle | adult stage | somatic clone

      (Stern et al., 2009)

      posterior dorsocentral bristle | adult stage | somatic clone | increased number

      (Stern et al., 2009)

      posterior dorsocentral bristle | pharate adult stage (with CtBP03463)

      (Stern et al., 2009)

      posterior dorsocentral bristle | pharate adult stage | increased number (with CtBP03463)

      (Stern et al., 2009)

      posterior notopleural bristle | adult stage | somatic clone

      (Stern et al., 2009)

      posterior notopleural bristle | adult stage | somatic clone | increased number

      (Stern et al., 2009)

      posterior orbital bristle | somatic clone - Minute background

      (Hoang et al., 2010)

      posterior postalar bristle | adult stage | somatic clone | increased number

      (Stern et al., 2009)

      posterior postalar bristle | pharate adult stage | increased number (with CtBP03463)

      (Stern et al., 2009)

      posterior scutellar bristle | adult stage | somatic clone

      (Stern et al., 2009)

      posterior scutellar bristle | adult stage | somatic clone | increased number

      (Stern et al., 2009)

      posterior scutellar bristle | pharate adult stage (with CtBP03463)

      (Stern et al., 2009)

      posterior scutellar bristle | pharate adult stage | increased number (with CtBP03463)

      (Stern et al., 2009)

      posterior supraalar bristle | adult stage | somatic clone

      (Stern et al., 2009)

      posterior supraalar bristle | adult stage | somatic clone | increased number

      (Stern et al., 2009)

      posterior supraalar bristle | pharate adult stage | increased number (with CtBP03463)

      (Stern et al., 2009)

      second segment of antenna | pharate adult stage (with Df(3R)ry615)

      (Hoang et al., 2010)

      third segment of antenna | pharate adult stage (with Df(3R)ry615)

      (Hoang et al., 2010)

      tormogen cell | adult stage | somatic clone

      (Stern et al., 2009)

      vertical bristle 2 | pharate adult stage (with CtBP03463)

      (Hoang et al., 2010)

      vertical bristle 2 | somatic clone - Minute background

      (Hoang et al., 2010)

      vertical bristle | pharate adult stage | increased number (with CtBP03463)

      (Hoang et al., 2010)

      vertical bristle | somatic clone - Minute background | increased number

      (Hoang et al., 2010)
      Detailed Description
      Statement
      Reference

      CtBP87De-10 clones in wing imaginal discs do not cause apoptosis compared to controls.

      CtBP87De-10/+ adults do not exhibit ectopic wings compared to controls.

      (Worley et al., 2018)

      CtBP87De-10/+ adult flies have one trichogen (hair) and one tormogen (socket) cell per notal microchaeta, similar to wild-type controls.

      (Endo et al., 2011)

      CtBP87De-10 heterozygotes do not exhibit any size alterations or roughness in eyes when compared to control adults.

      CtBP87De-10/CtBP03463 exhibit following eye defects: large and mildly rough eyes with a decrease in the number of interommatidial bristles, and a significant increase in the number of ommatidia; and following head defects: occasional duplicated vertical and orbital bristles, occasional double and/or misoriented orbital and postvertical bristles, and variable loss of interocellar and frontal bristles, large ocelli and surrounding ocellar cuticle while similar distance across the dorsal head between eyes when compared to control pharate adults.

      CtBP87De-10/Df(3R)ry615 exhibit a significant increase in the number of ommatidia and following defects in antenna: second and third antennal segments are somewhat larger, the aristae are slightly shorter with the main shaft tapering more prominently along the proximal-distal axis and branches from the main shaft are curved, and the number of bristles on second segment is reduced while Johnston's organs appear normal when compared to control pharate adults.

      Almost all mosaic animals with CtBP87De-10 homozygous clones and many mosaic animals with clones (in Minute background), both comprising most of the eye-antennal disc derived structures in the adult head, survive to adulthood as in controls.

      Mosaic animals with CtBP87De-10 clones (in Minute background) exhibit increased eye size, minor antennal defects and following head defects: loss of most post-vertical, ocellar, frontal, postorbital, and all interocellar bristles; one or more vertical bristles with extra or double bristles; occasionally missing or duplicated orbital bristles; large ocelli and surrounding ocellar cuticle while they exhibit similar distance across the dorsal head between eyes and no significant change in the number of ommatidia

      compared to control adults.

      Mosaic animals with CtBP87De-10 clones exhibit larger pre-morphogenetic-furrow clones with significantly more cell proliferation (PH3 staining); and animals with clones (in Minute background) exhibit gaps in the developing ommatidial array when compared to control clones in the third instar larval eye-antennal discs.

      (Hoang et al., 2010)

      CtBP03463/CtBP87De-10 heterozygous pharates display extra dorsal thoracic mechanosensory bristles (additional bristles attached to sockets) and, less frequently, double bristles (two bristles housed in the same socket structure) and bald cuticle (complete loss of both bristles and their associated sockets). Only a subset of bristles are affected.

      Within CtBP87De-10 dorsal thorax clones, extra bristles, double bristles forming from the same socket, bald cuticle, and sockets lacking bristles are observed. All but the presutural bristle appear to be affected. The double bristle phenotypes appear exclusively at the anterior scutellar bristle and posterior dorsocentral bristle positions. Bald cuticle appears in all regions except the posterior postalar bristle and presutural regions. Socket without bristle phenotype is observed for all positions except the presutural position.

      A putative cell polarity abnormality of the microchaetes is observed in CtBP87De-10 dorsal thorax clones.

      (Stern et al., 2009)

      CtBP87De-10 mutant cyst progenitor cell clones cannot be recovered.

      (Leatherman and DiNardo, 2008)

      About 65% of CtBP87De-10, CtBPUbi.T:Hsap\MYC flies show an extra macrochaete phenotype on the dorsal thorax.

      (Stern et al., 2007)

      Heterozygotes occasionally have bristle with a double-socket phenotype. CtBP03463/CtBP87De-10 pharate adults show bristle shaft defects and shaft loss.

      (Barolo et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      Enhancer of
      Statement
      Reference

      CtBP[+]/CtBP87De-10 is an enhancer of visible | adult stage | dominant phenotype of brm2

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is an enhancer of visible | adult stage | dominant phenotype of trx1

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is an enhancer of visible | adult stage | dominant phenotype of trxE2

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is an enhancer of visible | adult stage | dominant phenotype of ash1B1

      (Bi et al., 2022)

      CtBP87De-10/CtBP87De-10 is an enhancer of increased size | adult stage | somatic clone - tissue specific phenotype of sav2

      (Vissers et al., 2020)

      CtBP87De-10/CtBP87De-10 is an enhancer of visible | adult stage | somatic clone - tissue specific phenotype of sav2

      (Vissers et al., 2020)

      CtBP87De-10/CtBP87De-10 is an enhancer of increased cell number | P-stage | somatic clone - tissue specific phenotype of sav2

      (Vissers et al., 2020)

      CtBP[+]/CtBP87De-10 is an enhancer of visible | adult stage phenotype of BacA\p35UAS.cHa, Scer\GAL4rn-GAL4-5, egrUAS.cUa

      (Worley et al., 2018)

      CtBP[+]/CtBP87De-10 is an enhancer of visible | adult stage phenotype of Scer\GAL4rn-GAL4-5, egrUAS.cUa, upd1UAS.cUa

      (Worley et al., 2018)

      CtBP[+]/CtBP87De-10 is an enhancer of visible | adult stage phenotype of CtBPUAS.Tag:FLAG, Scer\GAL4rn-GAL4-5, egrUAS.cUa

      (Worley et al., 2018)

      CtBP[+]/CtBP87De-10 is an enhancer of visible | adult stage phenotype of Scer\GAL4rn-GAL4-5, egrecto-60.UAS.Tag:HA,Tag:FLAG

      (Worley et al., 2018)

      CtBP87De-10/CtBP87De-10 is an enhancer of homeotic | adult stage | somatic clone - Minute background phenotype of danems3, danrex35

      (Hoang et al., 2010)

      CtBP87De-10/CtBP87De-10 is an enhancer of visible | adult stage | somatic clone - Minute background phenotype of danems3, danrex35

      (Hoang et al., 2010)

      CtBP87De-10/CtBP87De-10 is an enhancer of abnormal neuroanatomy | adult stage | somatic clone - Minute background phenotype of danems3, danrex35

      (Hoang et al., 2010)

      danems3, danems3, CtBP87De-10, CtBP87De-10 is an enhancer of homeotic | adult stage | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      danrex35, danrex35, CtBP87De-10, CtBP87De-10 is an enhancer of homeotic | adult stage | somatic clone - Minute background phenotype of danems3

      (Hoang et al., 2010)

      danrex35, danrex35, CtBP87De-10, CtBP87De-10 is an enhancer of visible | adult stage | somatic clone - Minute background phenotype of danems3

      (Hoang et al., 2010)

      CtBP87De-10/CtBP87De-10 is an enhancer of homeotic | adult stage | somatic clone - Minute background phenotype of danems3

      (Hoang et al., 2010)

      CtBP87De-10/CtBP87De-10 is an enhancer of visible | adult stage | somatic clone - Minute background phenotype of danems3

      (Hoang et al., 2010)

      CtBP87De-10/CtBP87De-10 is an enhancer of homeotic | adult stage | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      CtBP87De-10/CtBP87De-10 is an enhancer of abnormal size | adult stage | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      CtBP87De-10/CtBP87De-10 is an enhancer of visible | adult stage | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is an enhancer of visible phenotype of Df(1)os1

      (Mukherjee et al., 2006)

      CtBP[+]/CtBP87De-10 is an enhancer of visible phenotype of Su(H)RC-9Xm

      (Barolo et al., 2002)

      CtBP[+]/CtBP87De-10 is an enhancer of visible | dominant phenotype of HE31

      (Barolo et al., 2002)
      NOT Enhancer of
      Statement
      Reference

      CtBP[+]/CtBP87De-10 is a non-enhancer of visible | adult stage phenotype of Scer\GAL4rn-GAL4-5, hepCA.UAS

      (Worley et al., 2018)

      CtBP[+]/CtBP87De-10 is a non-enhancer of increased cell death | third instar larval stage phenotype of Scer\GAL4rn-GAL4-5, egrUAS.cUa

      (Worley et al., 2018)

      CtBP[+]/CtBP87De-10 is a non-enhancer of visible | adult stage phenotype of Scer\GAL4ptc.PU, wgUAS.cHa.Tag:HA

      (Worley et al., 2018)

      danems3, danems3, CtBP87De-10, CtBP87De-10 is a non-enhancer of abnormal size | adult stage | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is a non-enhancer of visible phenotype of upd1GMR.PB

      (Mukherjee et al., 2006)

      CtBP[+]/CtBP87De-10 is a non-enhancer of visible phenotype of H21

      (Barolo et al., 2002)

      CtBP[+]/CtBP87De-10 is a non-enhancer of visible phenotype of H21, groE73/gro[+]

      (Barolo et al., 2002)
      Suppressor of
      Statement
      Reference

      CtBP[+]/CtBP87De-10 is a suppressor | partially of homeotic | dominant | male | adult stage phenotype of Pc1

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of visible | dominant | male | adult stage phenotype of Pc1

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of homeotic | dominant | male | adult stage phenotype of Pc3

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of visible | dominant | male | adult stage phenotype of Pc3

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of homeotic | dominant | male | adult stage phenotype of ScmD1

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of visible | dominant | male | adult stage phenotype of ScmD1

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4sca-109-68, hamΔCtBP.UAS

      (Endo et al., 2011)

      CtBP[+]/CtBP87De-10 is a suppressor of visible | adult stage phenotype of Scer\GAL4sca-109-68, hamUAS.cMa

      (Endo et al., 2011)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4ey.PU, eyUAS.cHa

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4ey.PU, eyUAS.cHa

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4ey.PU, danrUAS.cEa

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4ey.PU, danrUAS.cEa

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4ey.PU, danUAS.cEa

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4ey.PU, danUAS.cEa

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is a suppressor of visible | heat sensitive phenotype of Nl1N-ts1

      (Barolo et al., 2002)
      NOT Suppressor of
      Statement
      Reference

      CtBP[+]/CtBP87De-10 is a non-suppressor of visible | adult stage phenotype of Scer\GAL4rn-GAL4-5, hepCA.UAS

      (Worley et al., 2018)

      CtBP[+]/CtBP87De-10 is a non-suppressor of increased cell death | third instar larval stage phenotype of Scer\GAL4rn-GAL4-5, egrUAS.cUa

      (Worley et al., 2018)

      CtBP[+]/CtBP87De-10 is a non-suppressor of visible | adult stage phenotype of Scer\GAL4ptc.PU, wgUAS.cHa.Tag:HA

      (Worley et al., 2018)

      danems3, danems3, CtBP87De-10, CtBP87De-10 is a non-suppressor of abnormal size | adult stage | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is a non-suppressor of visible phenotype of upd1GMR.PB

      (Mukherjee et al., 2006)

      CtBP[+]/CtBP87De-10 is a non-suppressor of visible phenotype of H21, groE73/gro[+]

      (Barolo et al., 2002)

      CtBP[+]/CtBP87De-10 is a non-suppressor of visible phenotype of H21

      (Barolo et al., 2002)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      CtBP87De-10 has eye | somatic clone - tissue specific phenotype, enhanceable by sav2/sav2

      (Vissers et al., 2020)

      CtBP87De-10 has adult head | somatic clone - tissue specific phenotype, enhanceable by sav2/sav2

      (Vissers et al., 2020)

      CtBP87De-10, Scer\GAL4rn-GAL4-5, egrUAS.cUa has wing | ectopic phenotype, enhanceable by BacA\p35UAS.cHa, Scer\GAL4rn-GAL4-5

      (Worley et al., 2018)

      CtBP87De-10, Scer\GAL4rn-GAL4-5, egrUAS.cUa has wing | ectopic phenotype, enhanceable by upd1UAS.cUa, Scer\GAL4rn-GAL4-5

      (Worley et al., 2018)

      CtBP87De-10, Scer\GAL4rn-GAL4-5, egrUAS.cUa has wing pouch | third instar larval stage | ectopic phenotype, enhanceable by upd1UAS.cUa, Scer\GAL4rn-GAL4-5

      (Worley et al., 2018)

      CtBP87De-10 has antenna | somatic clone - Minute background phenotype, enhanceable by danrex35/danrex35/danems3/danems3

      (Hoang et al., 2010)

      CtBP87De-10 has eye | somatic clone - Minute background phenotype, enhanceable by danrex35/danrex35/danems3/danems3

      (Hoang et al., 2010)

      CtBP87De-10 has eye disc | somatic clone - Minute background phenotype, enhanceable by danrex35/danrex35/danems3/danems3

      (Hoang et al., 2010)

      CtBP87De-10 has antenna | somatic clone - Minute background phenotype, enhanceable by danems3/danems3

      (Hoang et al., 2010)

      CtBP87De-10 has eye | somatic clone - Minute background phenotype, enhanceable by danems3/danems3

      (Hoang et al., 2010)

      CtBP87De-10 has antenna | somatic clone - Minute background phenotype, enhanceable by danrex35/danrex35

      (Hoang et al., 2010)

      CtBP87De-10 has eye | somatic clone - Minute background phenotype, enhanceable by danrex35/danrex35

      (Hoang et al., 2010)
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      Enhancer of
      Statement
      Reference

      CtBP[+]/CtBP87De-10 is an enhancer of abdominal tergite phenotype of brm2

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is an enhancer of abdominal tergite phenotype of trx1

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is an enhancer of abdominal tergite phenotype of trxE2

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is an enhancer of abdominal tergite phenotype of ash1B1

      (Bi et al., 2022)

      CtBP87De-10/CtBP87De-10 is an enhancer of eye | somatic clone - tissue specific phenotype of sav2

      (Vissers et al., 2020)

      CtBP87De-10/CtBP87De-10 is an enhancer of adult head | somatic clone - tissue specific phenotype of sav2

      (Vissers et al., 2020)

      CtBP87De-10/CtBP87De-10 is an enhancer of interommatidial cell | P-stage | somatic clone - tissue specific phenotype of sav2

      (Vissers et al., 2020)

      CtBP[+]/CtBP87De-10 is an enhancer of wing | ectopic phenotype of BacA\p35UAS.cHa, Scer\GAL4rn-GAL4-5, egrUAS.cUa

      (Worley et al., 2018)

      CtBP[+]/CtBP87De-10 is an enhancer of wing disc | third instar larval stage phenotype of Scer\GAL4rn-GAL4-5, egrUAS.cUa

      (Worley et al., 2018)

      CtBP[+]/CtBP87De-10 is an enhancer of wing | ectopic phenotype of Scer\GAL4rn-GAL4-5, egrUAS.cUa, upd1UAS.cUa

      (Worley et al., 2018)

      CtBP[+]/CtBP87De-10 is an enhancer of wing | ectopic phenotype of CtBPUAS.Tag:FLAG, Scer\GAL4rn-GAL4-5, egrUAS.cUa

      (Worley et al., 2018)

      CtBP[+]/CtBP87De-10 is an enhancer of wing | ectopic phenotype of Scer\GAL4rn-GAL4-5, egrecto-60.UAS.Tag:HA,Tag:FLAG

      (Worley et al., 2018)

      CtBP87De-10/CtBP87De-10 is an enhancer of antenna | somatic clone - Minute background phenotype of danems3, danrex35

      (Hoang et al., 2010)

      CtBP87De-10/CtBP87De-10 is an enhancer of eye | somatic clone - Minute background phenotype of danems3, danrex35

      (Hoang et al., 2010)

      danems3, danems3, CtBP87De-10, CtBP87De-10 is an enhancer of antenna | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      danrex35, danrex35, CtBP87De-10, CtBP87De-10 is an enhancer of antenna | somatic clone - Minute background phenotype of danems3

      (Hoang et al., 2010)

      CtBP87De-10/CtBP87De-10 is an enhancer of antenna | somatic clone - Minute background phenotype of danems3

      (Hoang et al., 2010)

      CtBP87De-10/CtBP87De-10 is an enhancer of eye | somatic clone - Minute background phenotype of danems3

      (Hoang et al., 2010)

      CtBP87De-10/CtBP87De-10 is an enhancer of antenna | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      CtBP87De-10/CtBP87De-10 is an enhancer of ommatidium | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      CtBP87De-10/CtBP87De-10 is an enhancer of eye | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is an enhancer of eye phenotype of Df(1)os1

      (Mukherjee et al., 2006)

      CtBP[+]/CtBP87De-10 is an enhancer of macrochaeta phenotype of Su(H)RC-9Xm

      (Barolo et al., 2002)

      CtBP[+]/CtBP87De-10 is an enhancer of anterior orbital bristle phenotype of HE31

      (Barolo et al., 2002)

      CtBP[+]/CtBP87De-10 is an enhancer of macrochaeta phenotype of HE31

      (Barolo et al., 2002)

      CtBP87De-10 is an enhancer of eye phenotype of Hsap\ATXN182Q.UAS, Scer\GAL4GMR.PF

      (Fernandez-Funez et al., 2000)

      CtBP87De-10 is an enhancer of retina phenotype of Hsap\ATXN182Q.UAS, Scer\GAL4GMR.PF

      (Fernandez-Funez et al., 2000)

      CtBP[+]/CtBP87De-10 is an enhancer of eye phenotype of Scer\GAL4hs.2sev, ttk69.UAS.Tag:HA

      (Wen et al., 2000)
      NOT Enhancer of
      Statement
      Reference

      CtBP[+]/CtBP87De-10 is a non-enhancer of wing | ectopic phenotype of Scer\GAL4rn-GAL4-5, hepCA.UAS

      (Worley et al., 2018)

      CtBP[+]/CtBP87De-10 is a non-enhancer of wing | ectopic phenotype of Scer\GAL4ptc.PU, wgUAS.cHa.Tag:HA

      (Worley et al., 2018)

      danems3, danems3, CtBP87De-10, CtBP87De-10 is a non-enhancer of ommatidium | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      danems3, danems3, CtBP87De-10, CtBP87De-10 is a non-enhancer of eye | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is a non-enhancer of eye phenotype of upd1GMR.PB

      (Mukherjee et al., 2006)

      CtBP[+]/CtBP87De-10 is a non-enhancer of macrochaeta phenotype of H21

      (Barolo et al., 2002)

      CtBP[+]/CtBP87De-10 is a non-enhancer of macrochaeta phenotype of H21, groE73/gro[+]

      (Barolo et al., 2002)
      Suppressor of
      Statement
      Reference

      CtBP[+]/CtBP87De-10 is a suppressor | partially of prothoracic leg | ectopic | male phenotype of Pc1

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor of metathoracic leg | male phenotype of Pc1

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of mesothoracic leg | male phenotype of Pc1

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of wing phenotype of Pc1

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of prothoracic leg | ectopic | male phenotype of Pc3

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of metathoracic leg | male phenotype of Pc3

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of wing phenotype of Pc3

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of prothoracic leg | ectopic | male phenotype of ScmD1

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of mesothoracic leg | male phenotype of ScmD1

      (Bi et al., 2022)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of notal microchaeta | adult stage phenotype of Scer\GAL4sca-109-68, hamΔCtBP.UAS

      (Endo et al., 2011)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of tormogen cell | adult stage phenotype of Scer\GAL4sca-109-68, hamΔCtBP.UAS

      (Endo et al., 2011)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of trichogen cell | ectopic | adult stage phenotype of Scer\GAL4sca-109-68, hamΔCtBP.UAS

      (Endo et al., 2011)

      CtBP[+]/CtBP87De-10 is a suppressor of notal microchaeta | adult stage phenotype of Scer\GAL4sca-109-68, hamUAS.cMa

      (Endo et al., 2011)

      CtBP[+]/CtBP87De-10 is a suppressor of tormogen cell | adult stage phenotype of Scer\GAL4sca-109-68, hamUAS.cMa

      (Endo et al., 2011)

      CtBP[+]/CtBP87De-10 is a suppressor of trichogen cell | ectopic | adult stage phenotype of Scer\GAL4sca-109-68, hamUAS.cMa

      (Endo et al., 2011)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of eye phenotype of Scer\GAL4ey.PU, eyUAS.cHa

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is a suppressor | partially of eye phenotype of Scer\GAL4ey.PU, danUAS.cEa

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is a suppressor of chaeta | heat sensitive phenotype of Nl1N-ts1

      (Barolo et al., 2002)
      NOT Suppressor of
      Statement
      Reference

      CtBP[+]/CtBP87De-10 is a non-suppressor of wing | ectopic phenotype of Scer\GAL4rn-GAL4-5, hepCA.UAS

      (Worley et al., 2018)

      CtBP[+]/CtBP87De-10 is a non-suppressor of wing | ectopic phenotype of Scer\GAL4ptc.PU, wgUAS.cHa.Tag:HA

      (Worley et al., 2018)

      danems3, danems3, CtBP87De-10, CtBP87De-10 is a non-suppressor of ommatidium | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      danems3, danems3, CtBP87De-10, CtBP87De-10 is a non-suppressor of eye | somatic clone - Minute background phenotype of danrex35

      (Hoang et al., 2010)

      CtBP[+]/CtBP87De-10 is a non-suppressor of eye phenotype of upd1GMR.PB

      (Mukherjee et al., 2006)

      CtBP[+]/CtBP87De-10 is a non-suppressor of macrochaeta phenotype of H21, groE73/gro[+]

      (Barolo et al., 2002)

      CtBP[+]/CtBP87De-10 is a non-suppressor of macrochaeta phenotype of H21

      (Barolo et al., 2002)
      Other
      Statement
      Reference

      CtBP87De-10, Scer\GAL4GMR76A01, Scer\GAL4nub-AC-62, egrUAS.cUa has wing | ectopic phenotype

      (Worley et al., 2018)

      CtBP87De-10, Scer\GAL4rn-GAL4-5, egrUAS.cUa has wing | ectopic phenotype

      (Worley et al., 2018)

      CtBP87De-10, Scer\GAL4rn-GAL4-5, egrUAS.cUa has wing pouch | ectopic | third instar larval stage phenotype

      (Worley et al., 2018)

      CtBP87De-10, Scer\GAL4ptc.PU, wgUAS.cHa.Tag:HA has wing pouch | ectopic phenotype

      (Worley et al., 2018)

      CtBP87De-10, Scer\GAL4GMR15B03, Scer\GAL4nub-AC-62, egrUAS.cUa has wing | ectopic phenotype

      (Worley et al., 2018)

      CtBP87De-10, Scer\GAL4nub-AC-62, egrUAS.cUa has wing | ectopic phenotype

      (Worley et al., 2018)

      CtBP87De-10, danems3, danrex35 has eye photoreceptor cell | adult stage | somatic clone - Minute background phenotype

      (Hoang et al., 2010)

      CtBP87De-10, danems3, danrex35 has inner photoreceptor cell | adult stage | somatic clone - Minute background phenotype

      (Hoang et al., 2010)

      CtBP87De-10, danems3, danrex35 has outer photoreceptor cell | adult stage | somatic clone - Minute background phenotype

      (Hoang et al., 2010)

      CtBP87De-10, danems3 has eye | somatic clone - Minute background phenotype

      (Hoang et al., 2010)

      CtBP87De-10, danems3 has ommatidium | somatic clone - Minute background phenotype

      (Hoang et al., 2010)

      CtBP87De-10, danrex35 has eye | somatic clone - Minute background phenotype

      (Hoang et al., 2010)

      CtBP87De-10, danrex35 has ommatidium | somatic clone - Minute background phenotype

      (Hoang et al., 2010)

      CtBP87De-10, Df(3R)awd-KRB has wing margin bristle | ectopic phenotype

      (Badenhorst et al., 2002)

      CtBP87De-10, hry41 has wing margin bristle | ectopic phenotype

      (Badenhorst et al., 2002)

      CtBP87De-10, ttkrM730 has wing margin bristle | ectopic phenotype

      (Badenhorst et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In CtBP87De-10/+ background expression of egrUAS.cUa under the control of Scer\GAL4rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) leads to either no ectopic wings (in majority) or ectopic wings (24-hour-expression yielding a lower frequency than 40-hour-expression) on one or two sides compared to controls. Ectopic wings occur most frequently when expression is induced on early stages of third instar larvae. After expression has ceased, wing discs exhibit morphological changes associated with the outgrowth of an ectopic wing pouch from the posterior edge of the notum.

      Expression of rprUAS.cUa, wgUAS.cHa.Tag:HA, grndintra.UAS, upd1UAS.cUa or hepUAS.cUa under the control of Scer\GAL4rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) in CtBP87De-10/+ background does not lead to ectopic wings (or ectopic wing pouches in wing discs with upd1UAS.cUa) compared to controls.

      Restricted expression of wgUAS.cHa.Tag:HA to second but not third instar larvae (under the control of Scer\GAL4ptc.PU and tub-Gal80[ts]) leads to ectopic wing pouches in wing discs in CtBP87De-10/+ background compared to controls.

      40-hour- (but not 24-hour-) expression of hepCA.UAS under the control of Scer\GAL4rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) in CtBP87De-10/+ background leads to occasional ectopic wings compared to controls.

      (Worley et al., 2018)

      Mosaic animals with CtBP87De-10 danems3 double homozygous clones exhibit significantly fewer ommatidia than single homozygous mosaic eyes and control clones.

      Mosaic animals with CtBP87De-10 danems3 danrex35 triple homozygous clones (in Minute background) exhibit defects in ommatidia with a higher frequency when compared to danems3 danrex35 double homozygous clones (in Minute background).

      (Hoang et al., 2010)

      CtBP87De-10 combined with h41, ttkrM730 or Df(3R)awd-KRB leads to an ectopic margin bristle phenotype.

      (Badenhorst et al., 2002)

      CtBP87De-10 dominantly enhances the bristle defects seen in HE31/+ flies. This enhancement is almost entirely due to shaft-socket transformations, with only a mild effect on bristle loss.

      (Barolo et al., 2002)

      Some of the eye phenotypes caused by expression of ttk69.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4hs.2sev are enhanced by one copy of CtBP87De-10.

      (Wen et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference

      Atha\ANUbi.T:Hsap\MYC fails to rescue CtBP87De-10 zygotic lethality.

      (Stern et al., 2007)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Gelbart.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (13)
      References (30)