FlyBase Allele Report: Dmel\E(z)[1]

General Information

Symbol

Dmel\E(z)¹

Species

D. melanogaster

Name

FlyBase ID

FBal0003380

Feature type

allele

Associated gene

Dmel\E(z)

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

neomorphic allele - genetic evidence

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Laible et al., 1997)

gain of function allele

(Cheng et al., 1994, Jones and Gelbart, 1993, Jones and Gelbart, 1990)

neomorphic allele - genetic evidence

(LaJeunesse and Shearn, 1996)

Mutagen

ethyl methanesulfonate

(Phillips and Shearn, 1990, Kalisch and Rasmuson, 1974)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Jones and Gelbart, 1990)

Description

Amino acid replacement: Y655N.

(Joshi et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:10,634,958..10,634,958 [-]

Nucleotide change:

T10634958A

Amino acid change:

Y655N | E(z)-PA; Y655N | E(z)-PB; Y660N | E(z)-PC

Reported amino acid change:

Y655N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Joshi et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Jones and Gelbart, 1993)

lethal | recessive

(Jones and Gelbart, 1990, Phillips and Shearn, 1990, Kalisch and Rasmuson, 1974)

Phenotype Manifest In

pigment cell

(Kalisch and Rasmuson, 1974)

Detailed Description

Statement

Reference

A significant change in repression of the w^H19.UZA gene compared to offspring from the same cross carrying the balancer chromosome is observed in E(z)¹ flies. Β-galactosidase assays on heterozygous larvae with the E(z)¹ allele show a two- to threefold stronger repression of Ecol\lacZ compared to Ecol\lacZ wild-type flies.

(Erhardt et al., 2003)

The total level of hydrocarbons and the level of 7-monoenes is significantly increased in heterozygous males compared to controls. The total level of hydrocarbons is significantly increased and the level of 7,11-dienes is significantly decreased in heterozygous females compared to controls.

(Wicker-Thomas and Jallon, 2000)

Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w^+mW.hs allele at the telomeres of the second and third chromosomes.

(Cryderman et al., 1999)

Phenotypically like ash1²⁹.

(LaJeunesse and Shearn, 1996)

In z¹ w^zm strain mutation causes reduction of eye pigmentation.

(Georgiev, 1994)

Dominant enhancer of z¹.

(Jones and Gelbart, 1990)

The z enhancement phenotype of E(z)¹ is unaffected by Dp(3;3)S2a3.

(Phillips and Shearn, 1990)

gain-of-function allele

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

E(z)[+]/E(z)¹ is an enhancer of abnormal eye color | female phenotype of g^53d, z[+]/z¹

(Lloyd et al., 2002)

E(z)¹ is an enhancer of abnormal eye color | male phenotype of g^53d, z¹

(Lloyd et al., 2002)

E(z)[+]/E(z)¹ is an enhancer of abnormal eye color | female phenotype of g^53d/g[+], z¹

(Lloyd et al., 2002)

NOT Enhancer of

Statement

Reference

E(z)¹ is a non-enhancer of abnormal eye color phenotype of g⁴

(Lloyd et al., 2002)

E(z)¹ is a non-enhancer of abnormal eye color phenotype of g²

(Lloyd et al., 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

E(z)[+]/E(z)¹ is an enhancer of pigment cell | female phenotype of g^53d/g[+], z¹

(Lloyd et al., 2002)

E(z)[+]/E(z)¹ is an enhancer of pigment cell | female phenotype of g^53d, z[+]/z¹

(Lloyd et al., 2002)

E(z)¹ is an enhancer of pigment cell | male phenotype of g^53d, z¹

(Lloyd et al., 2002)

E(z)¹ is an enhancer | male of pigment cell phenotype of g^53d, z¹

(Lloyd et al., 2002)

E(z)¹ is an enhancer of phenotype of z¹

(Jones and Gelbart, 1990, Kalisch and Rasmuson, 1974)

NOT Enhancer of

Statement

Reference

E(z)¹ is a non-enhancer of pigment cell phenotype of g⁴

(Lloyd et al., 2002)

E(z)¹ is a non-enhancer of pigment cell phenotype of g²

(Lloyd et al., 2002)

Other

Statement

Reference

E(z)¹, ash1²⁸ has metathoracic leg phenotype

(LaJeunesse and Shearn, 1996)

E(z)¹, ash1²⁸ has prothoracic leg phenotype

(LaJeunesse and Shearn, 1996)

E(z)¹, ash1²⁹ has metathoracic leg phenotype

(LaJeunesse and Shearn, 1996)

E(z)¹, ash1²⁹ has prothoracic leg phenotype

(LaJeunesse and Shearn, 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Male E(z)¹/+, g^53d, z¹ triple mutants have less red pigment in the eye than g^53d, z¹ double mutants. Likewise, female E(z)¹/+, g^53d/+, z¹/+ triple mutants have a reduction in red eye pigment compared to g^53d/+, z¹/+ double mutants. The E(z)¹ mutation does not affect levels of red pigment in the eye of g² or g⁴ mutants.

(Lloyd et al., 2002)

Double heterozygotes of E(z)¹ with ash1²⁸ or ash1²⁹ result in transformations of the third leg to the second leg and first leg to second leg. This phenotype is that expected from partial loss of function of Scr and Ubx.

(LaJeunesse and Shearn, 1996)

Strongly influences the z/w interaction causing the eye colour to change to intense yellow or yellow-brown.

(Kalisch and Rasmuson, 1974)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

E(z)⁵

(Phillips and Shearn, 1990)

Rescued by

E(z)¹ is rescued by E(z)^+t8.8

(Jones and Gelbart, 1993)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Acts as an antimorphic trx-group mutation.

(LaJeunesse and Shearn, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

E(z)1

(Lloyd et al., 2002, Gvozdev et al., 2000)

E(z)¹

(Joshi et al., 2008, Wicker-Thomas and Jallon, 2000)

Name Synonyms

Secondary FlyBase IDs

References (23)

Report Sections

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