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Vertex Pharmaceuticals Incorporated (VRTX)

472.01 +2.11 (+0.45%)
At close: February 2 at 4:00:00 PM EST
473.10 +1.09 (+0.23%)
After hours: 7:48:21 PM EST
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News headlines Vertex Pharmaceuticals is navigating a challenging landscape marked by setbacks in its pain management program and recent licensing agreements. Despite these hurdles, upcoming earnings reports and analyst upgrades may provide insights into its future performance.

Vertex Pharmaceuticals is navigating a challenging landscape marked by setbacks in its pain management program and recent licensing agreements. Despite these hurdles, upcoming earnings reports and analyst upgrades may provide insights into its future performance.

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  • Previous Close 469.90
  • Open 465.65
  • Bid 469.51 x 100
  • Ask 470.38 x 100
  • Day's Range 464.01 - 473.74
  • 52 Week Range 362.50 - 519.68
  • Volume 759,623
  • Avg. Volume 1,421,806
  • Market Cap (intraday) 121.019B
  • Beta (5Y Monthly) 0.32
  • PE Ratio (TTM) 33.22
  • EPS (TTM) 14.21
  • Earnings Date Feb 12, 2026
  • Forward Dividend & Yield --
  • Ex-Dividend Date --
  • 1y Target Est 514.32

Vertex Pharmaceuticals Incorporated, a biotechnology company, engages in developing and commercializing therapies for treating cystic fibrosis (CF). It markets TRIKAFTA/KAFTRIO for people with CF with at least one F508del mutation for 2 years of age and older; ALYFTREK for the treatment for people with CF 6 years of age and older; SYMDEKO/SYMKEVI for treatment of patients with CF 6 years of age and older; ORKAMBI for CF patients 1 year or older; and KALYDECO for the treatment of patients with 1 month or older who have CF with ivacaftor. The company also develops CASGEVY for the treatment of sickle cell disease and transfusion-dependent beta thalassemia; JOURNAVX for the treatment of acute pain in adults; VX-522, a CFTR mRNA therapeutic designed to treat the underlying cause of CF, which is in Phase 1/2 clinical trial; inaxaplin for the treatment of APOL1-mediated kidney disease which is in single Phase 2; VX-880 and VX-264, treatment for Type 1 Diabetes; VX-670 for the treatment of myotonic dystrophy type 1; and VX-407, a small molecule corrector for the treatment of autosomal dominant polycystic kidney disease. Further, it sells the products to specialty pharmacy and specialty distributors in the United States, as well as retail pharmacies, hospitals, and clinics. Additionally, the company has collaborations with CRISPR Therapeutics AG.; Moderna, Inc.; and Entrada Therapeutics, Inc. Vertex Pharmaceuticals Incorporated was founded in 1989 and is headquartered in Boston, Massachusetts.

www.vrtx.com

6,100

Full Time Employees

December 31

Fiscal Year Ends

Performance Overview: VRTX

Trailing total returns as of 2/2/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC) .

YTD Return

VRTX
4.11%
S&P 500 (^GSPC)
1.91%

1-Year Return

VRTX
2.24%
S&P 500 (^GSPC)
15.49%

3-Year Return

VRTX
55.38%
S&P 500 (^GSPC)
66.91%

5-Year Return

VRTX
117.19%
S&P 500 (^GSPC)
82.33%

Earnings Trends: VRTX

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Earnings Per Share

GAAP
Normalized
GAAP
Normalized
 

Revenue vs. Earnings

Annual
Quarterly
Annual
Quarterly
Q3 FY25
Revenue 3.08B
Earnings 1.24B

Q4

FY24

Q1

FY25

Q2

FY25

Q3

FY25

0
1B
2B
3B
 

Analyst Insights: VRTX

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Analyst Price Targets

330.00 Low
514.32 Average
472.01 Current
625.00 High
 

Analyst Recommendations

  • Strong Buy
  • Buy
  • Hold
  • Underperform
  • Sell
 

Latest Rating

Date 1/28/2026
Analyst Barclays
Rating Action Upgrade
Rating Overweight
Price Action Raises
Price Target 414 -> 606
 

Statistics: VRTX

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Valuation Measures

Annual
As of 1/30/2026
  • Market Cap

    120.69B

  • Enterprise Value

    116.24B

  • Trailing P/E

    33.07

  • Forward P/E

    24.04

  • PEG Ratio (5yr expected)

    --

  • Price/Sales (ttm)

    10.35

  • Price/Book (mrq)

    6.88

  • Enterprise Value/Revenue

    9.79

  • Enterprise Value/EBITDA

    24.62

Financial Highlights

Profitability and Income Statement

  • Profit Margin

    31.35%

  • Return on Assets (ttm)

    12.04%

  • Return on Equity (ttm)

    22.31%

  • Revenue (ttm)

    11.72B

  • Net Income Avi to Common (ttm)

    3.68B

  • Diluted EPS (ttm)

    14.21

Balance Sheet and Cash Flow

  • Total Cash (mrq)

    6.29B

  • Total Debt/Equity (mrq)

    10.59%

  • Levered Free Cash Flow (ttm)

    2.91B

Compare To: VRTX

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Company Insights: VRTX

Fair Value

472.01 Current
 

Dividend Score

0 Low
Sector Avg.
100 High
 

Hiring Score

0 Low
Sector Avg.
100 High
 

Insider Sentiment Score

0 Low
Sector Avg.
100 High
 

Research Reports: VRTX

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    The S&P 500, Dow Jones Industrial Average, and Nasdaq Composite are trying to stay above water at midday on Friday, this as a losing week for stocks comes to an end. As of this writing, the three majors are between 0.36% higher and 0.20% lower, as new catalysts for higher prices are hard to find and ongoing worries about an AI bubble and the future of interest rates remain firmly in the mindset of many investors.

     
  • Newly launched Alyftrek approaches blockbuster status

    Vertex Pharmaceuticals develops therapies to address cystic fibrosis and other diseases. The company was founded in 1989 in Cambridge, Massachusetts and has 6,100 employees. It has research programs and facilities in the U.S., the U.K., and Canada. The shares are a component of the S&P 500.

    Rating
    Price Target
     
  • Vertex Earnings: Trikafta Drives Solid Growth, but Slow Sales From Other Products in Portfolio

    Vertex Pharmaceuticals is a global biotechnology company that discovers and develops small-molecule drugs for the treatment of serious diseases. Its key drugs are Kalydeco, Orkambi, Symdeko, and Trikafta/Kaftrio, and Alyftrek for cystic fibrosis, where Vertex therapies remain the standard of care globally. Vertex has diversified its portfolio through Casgevy, a gene-editing therapy for beta thalassemia and sickle-cell disease, and Journavx, a non-opioid pain medication approved for the treatment of moderate-to-severe acute pain in adults. Additionally, Vertex is evaluating small-molecule inhibitors of APOL1-mediated kidney diseases. Vertex is also investigating cell therapies to deliver a potential functional cure for type 1 diabetes.

    Rating
    Price Target
     

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