ENZYME entry: EC 3.1.3.67

PURL: https://purl.expasy.org/enzyme/EC/3.1.3.67

Accepted Name

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

Alternative Name(s)

phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase

Reaction catalysed

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate

Comment(s)

Does not dephosphorylate inositol 4,5-bisphosphate.
This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyzes Ins(1,3,4,5)P4 to Ins(1,4,5)P3.

Cross-references

Rhea expert-curated reactions

3.1.3.67

ExplorEnz

3.1.3.67

IUBMB Enzyme Nomenclature

3.1.3.67

UniProtKB/Swiss-Prot

Q54JL7, CNRN_DICDI	Q9FLZ5, PTEN1_ARATH	G5EE01, PTEN_CAEEL
P60483, PTEN_CANLF	Q8T9S7, PTEN_DICDI	P60484, PTEN_HUMAN
O08586, PTEN_MOUSE	O54857, PTEN_RAT	O94526, PTEN_SCHPO
Q9PUT6, PTEN_XENLA	Q9LT75, PTN2A_ARATH	Q8H106, PTN2B_ARATH
Q9UMZ3, PTPRQ_HUMAN	P0C5E4, PTPRQ_MOUSE	O88488, PTPRQ_RAT
P53916, TEP1_YEAST	Q6XPS3, TPTE2_HUMAN	Q4R6N0, TPTE2_MACFA

BRENDA

3.1.3.67

MetaCyc

3.1.3.67

KEGG Ligand Database for Enzyme Nomenclature

3.1.3.67

EC2PDB

3.1.3.67

MEDLINE

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