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ENZYME

ENZYME entry: EC 2.4.1.257

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.257
Accepted Name
GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase
Alternative Name(s)
GDP-Man:Man2GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase
Reaction catalysed
an alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)
Comment(s)
  • The biosynthesis of asparagine-linked glycoproteins utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway.
  • Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an alpha1,3-mannosylation (cf. EC 2.4.1.132) of D-Man-beta-(1->4)-D- GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol, followed by an alpha1,6- mannosylation, to form the first branched pentasaccharide intermediate of the dolichol pathway.
Cross-references
BRENDA2.4.1.257
EC2PDB2.4.1.257
ExplorEnz2.4.1.257
KEGG Ligand Database for Enzyme Nomenclature2.4.1.257
IUBMB Enzyme Nomenclature2.4.1.257
MEDLINEFind literature relating to 2.4.1.257
MetaCyc2.4.1.257
Rhea expert-curated reactions2.4.1.257
UniProtKB/Swiss-Prot
Q59LF2, ALG2_CANALQ6FJJ9, ALG2_CANGAQ6BVA4, ALG2_DEBHA
Q7KWM5, ALG2_DICDIQ755C1, ALG2_EREGSQ9H553, ALG2_HUMAN
Q6CWQ0, ALG2_KLULAQ9DBE8, ALG2_MOUSEQ8X0H8, ALG2_NEUCR
O94738, ALG2_RHIPUQ96WW6, ALG2_SCHPOQ6C3V7, ALG2_YARLI
P43636, ALG2_YEAST

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