TAAR9
| TAAR9 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | TAAR9, TA3, TAR3, TAR9, TRAR3, trace amine associated receptor 9 (gene/pseudogene), trace amine associated receptor 9 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 608282; MGI: 3527454; HomoloGene: 65286; GeneCards: TAAR9; OMA:TAAR9 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Trace amine-associated receptor 9 is a protein that in humans is encoded by the TAAR9 gene.[5][6]
TAAR9 is a member of a large family of rhodopsin G protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][6] N-Methyl piperidine is a ligand of TAAR9 associated with aversive behavior in mice. N,N-dimethylcyclohexylamine is an additional binding agonist that also activaes TAAR7 variants.[7][8]
Recent research has demonstrated that deletion of the TAAR9 gene in rats leads to significant changes in both the CNS and the periphery. In the central nervous system, knockout of this gene slightly increases hippocampal serotonin and alters grooming behavior.[9] Peripherally, blood analysis revealed decreased levels of low-density lipoprotein cholesterol in the blood.[10] Additionally, TAAR9 appears to play a significant role in maintaining microbiota homeostasis. In TAAR9-KO rats, the microbiome structure exhibited greater variability than in wild-type littermates.[11]
See also
[edit]References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000237110 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037424 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
- ^ a b "Entrez Gene: TAAR9 trace amine associated receptor 9".
- ^ Ferrero DM, Wacker D, Roque MA, Baldwin MW, Stevens RC, Liberles SD (July 2012). "Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity". ACS Chemical Biology. 7 (7): 1184–9. doi:10.1021/cb300111e. PMC 3401279. PMID 22545963.
- ^ Liberles SD (October 2015). "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Current Opinion in Neurobiology. 34: 1–7. doi:10.1016/j.conb.2015.01.001. PMC 4508243. PMID 25616211.
- ^ Zhukov IS, Karpova IV, Murtazina RZ, Alnefeesi Y, Korenkova OM, Tissen IY, Palchikova SA, Tokareva LA, Pyurveev SS, Shabanov PD, Kubarskaya LG, Rozhko MA, Zernova EB, Zolotoverkhaja EA, Volnova AB, Kalueff AV, Alenina NV, Gainetdinov RR (12 November 2025). "TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats". Frontiers in Pharmacology. 16 1684029. doi:10.3389/fphar.2025.1684029. PMID 41311835.
- ^ Murtazina RZ, Zhukov IS, Korenkova OM, Popova EA, Kuvarzin SR, Efimova EV, et al. (March 2021). "Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels". International Journal of Molecular Sciences. 22 (6): 2942. doi:10.3390/ijms22062942. PMC 7998418. PMID 33799339.
- ^ Zhukov IS, Vaganova AN, Murtazina RZ, Alferova LS, Ermolenko EI, Gainetdinov RR (6 December 2022). "Gut Microbiota Alterations in Trace Amine-Associated Receptor 9 (TAAR9) Knockout Rats". Biomolecules. 12 (12): 1823. doi:10.3390/biom12121823. PMC 9775382. PMID 36551251.
Further reading
[edit]- Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, et al. (July 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proceedings of the National Academy of Sciences of the United States of America. 98 (16): 8966–71. Bibcode:2001PNAS...98.8966B. doi:10.1073/pnas.151105198. PMC 55357. PMID 11459929.
- Vanti WB, Muglia P, Nguyen T, Cheng R, Kennedy JL, George SR, O'Dowd BF (November 2003). "Discovery of a null mutation in a human trace amine receptor gene". Genomics. 82 (5): 531–6. doi:10.1016/S0888-7543(03)00173-3. PMID 14559210.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This transmembrane receptor-related article is a stub. You can help Wikipedia by adding missing information. |