The winners and runners-up of each of the eight groups in the Copa Sudamericana group stage as well as the third-placed teams of each of the eight groups in the Copa Libertadores group stage advanced to the final stages. The eight Copa Sudamericana group runners-up faced the eight Copa Libertadores group third-placed teams in the knockout round play-offs, whilst the eight Copa Sudamericana group winners directly advanced to the round of 16.
Copa Sudamericana group stage winners and runners-up
For the final stages, the teams were seeded according to their results in the group stage, with the Copa Sudamericana group winners seeded 1–8, the Copa Sudamericana group runners-up seeded 9–16, and the Copa Libertadores group third-placed teams seeded 17–24. For the round of 16 draw, the seeds 1–8 made up Pot 1, and the eight knockout round play-offs winners (seeds 9–24) made up Pot 2, keeping their seed. Teams from the same association may play each other from the knockout round play-offs onwards.
In the knockout round play-offs, round of 16, quarter-finals and semi-finals, each tie is played on a home-and-away two-legged basis, with the higher-seeded team hosting the second leg (Regulations Article 2.2.3). If tied on aggregate, extra time will not be played, and a penalty shoot-out will be used to determine the winners (Regulations Article 2.4.4).
The final is played as a single match at a venue pre-selected by CONMEBOL, with the higher-seeded team designated as the "home" team for administrative purposes (Regulations Article 2.2.6). If tied after regulation, 30 minutes of extra time will be played. If still tied after extra time, a penalty shoot-out will be used to determine the winners (Regulations Article 2.4.5).
The draw for the round of 16 was held on 2 June 2025, 12:00 PYT (UTC−3) at the CONMEBOL headquarters in Luque, Paraguay.[5] For the round of 16, the 16 teams were drawn into eight ties (A–H) between a Copa Sudamericana group winner (Pot 1) and a knockout round play-offs winner (Pot 2), with the group winners hosting the second leg. Teams from the same association or the same group could be drawn into the same tie (Regulations Article 2.2.3.2).[3][6]
^Match abandoned in the 47th minute of play with the score at 1–1 due to lack of security conditions.[31][32] The matter was referred by CONMEBOL to its Disciplinary Commission,[33] which subsequently disqualified Independiente from the competition.[34]
The final was played on 22 November 2025 in Asunción, Paraguay. Estadio Ramón Tahuichi Aguilera in Santa Cruz de la Sierra, Bolivia had been originally selected as the venue for the final,[61][62] but CONMEBOL announced the change of venue on 11 September 2025 due to delays in the works to prepare the stadium for the event.[4]
^San Antonio Bulo Bulo played their knockout round play-off home match at Estadio Félix Capriles, Cochabamba instead of their regular stadium Estadio Dr. Carlos Villegas, Entre Ríos which did not meet CONMEBOL requirements.
^Palestino played their knockout round play-off home match at Estadio Nacional Julio Martínez Prádanos, Santiago instead of their regular stadium Estadio Municipal de La Cisterna, Santiago which did not meet CONMEBOL requirements.
^Independiente del Valle played their knockout round play-off home match at Estadio Olímpico Atahualpa, Quito instead of their regular stadium Estadio Banco Guayaquil, Quito which was reserved for the 2025 Copa América Femenina.
^Guaraní played their knockout round play-off home match at Estadio General Pablo Rojas, Asunción (originally scheduled at Estadio Defensores del Chaco, Asunción) instead of their regular stadium Estadio Rogelio Livieres, Asunción which is being rebuilt.[23]
^ abCentral Córdoba play their home matches at Estadio Único Madre de Ciudades, Santiago del Estero instead of their regular stadium Estadio Alfredo Terrera, Santiago del Estero.
^Mushuc Runa played their round of 16 home match at Estadio Olímpico Atahualpa, Quito instead of their regular stadium Estadio Olímpico Fernando Guerrero, Riobamba which was unfit for use.[45]
^The Independiente v Universidad de Chile second leg match was suspended in the 47th minute of play with the score at 1–1 (Universidad de Chile leading 2–1 on aggregate) due to lack of security conditions. Disturbances were triggered by Universidad de Chile fans throwing objects towards the home crowd and violence escalated when Independiente fans broke into the away section to attack visiting fans and force them to flee. The referee suspended the match when fans entered the field of play and later, given the continuing lack of conditions, abandoned it.[31][32][50] In a statement, CONMEBOL confirmed the cancellation of the match and referred the matter to its Disciplinary Commission for resolution.[33] On 4 September 2025, CONMEBOL's Disciplinary Commission disqualified Independiente from the competition.[34]
^ abUniversidad de Chile played their quarter-final and semi-final home matches behind closed doors as punishment for the events of their round of 16 second leg match against Independiente.[34]