Highlights

  • X-rays impact gene expression

    Exposing the wing discs of Drosophila to X-rays leads to heterogenous changes in gene expression that are related to cell-cycle status and cell location.

    Joyner Cruz, William Y Sun ... Iswar K Hariharan
    Research Article

  • Reprogramming progenitor cells

    Progenitor cells destined to become glial cells can be reprogrammed to become corticospinal-like neurons

    Abdulkadir Ozkan, Hari K Padmanabhan ... Jeffrey D Macklis
    Research Article

  • Nanosprings probe motor proteins

    DNA nanosprings can measure stall forces in kinesin motor proteins, highlighting their potential as a new tool for force spectroscopy in biophysics.

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    Reviewed Preprint Updated

  • Research culture

    The Researcher Development Concordat has led to improvements in research culture in the UK, but there is still more to do.

    Robert AR Drake, Laura A Gray ... Joan Chang
    Feature Article

  • Where theory meets biology

    eLife author Veronika Koren, a computational neuroscientist, answers questions about her work on efficient coding.

    Inside eLife

  • What is a Reviewed Preprint?

    Reviewed Preprints provide benefits to authors and to the wider scientific community.

    Inside eLife
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    Rank- and Threat-Dependent Social Modulation of Innate Defensive Behaviors

    Ling-yun Li, Xinjian Gao, Ya-tang Li
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Dissociable dynamic effects of expectation during statistical learning

    Hannah H McDermott, Federico De Martino ... Ryszard Auksztulewicz
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Neuroscience

    Decoding state specific connectivity during speech production and perception

    Yasamin Esmaeili, Amirhossein Khalilian-Gourtani ... Adeen Flinker
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Multiple event segmentation mechanisms in the human brain

    Tan T Nguyen, Joset A Etzel ... Jeffrey M Zacks
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Simple Methods to Acutely Measure Multiple Timing Metrics among Sexual Repertoire of Male Drosophila

    Yutong Song, Dongyu Sun ... Woo Jae Kim
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location

    Joyner Cruz, William Y Sun ... Iswar K Hariharan
    Even in a simple epithelial tissue that is exposed uniformly to X-ray irradiation, cells show marked differences in their transcriptional response based on their location and cell-cycle status.
    1. Neuroscience

    Efficient and reproducible pipelines for spike sorting large-scale electrophysiology data

    Alessio P Buccino, Arjun Sridhar ... Joshua H Siegle
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Neuroscience

    Multi-Scale Anti-Correlated Neural States Dominate Naturalistic Whole-Brain Activity

    Dora Gözükara, Djamari Oetringer ... Linda Geerligs
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Improved sensory representations as a result of temporal adaptation

    Amber Marijn Brands, Zilan Oz ... Iris Isabelle Anna Groen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons

    Amanda Essoh, Xueyi Xie ... Jun Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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Magazine

    1. Structural Biology and Molecular Biophysics

    Receptor Proteins: Lipids challenge ligands to control receptors

    Adam JM Wollman
    1. Medicine
    2. Structural Biology and Molecular Biophysics

    Medical Imaging: MRI sets its sights on collagen

    Fritz Schick
    1. Developmental Biology

    Limb Patterning: The cellular logic of limb regeneration

    Matthew Cherubino, Catherine D McCusker
    1. Neuroscience

    Aging: Linking neuron-glia interactions and longevity

    Michael Pokrass, Nan Hao

  5. Research Culture: Going beyond compliance to build on the Researcher Development Concordat

    Robert AR Drake, Laura A Gray ... Joan Chang
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosomes: Finding a role for non-coding DNA in trypanosomes

    Markus R Schmidt
    1. Cancer Biology
    2. Cell Biology

    Chemotherapy: Lipid balance and chemoresistance in cancer cells

    Kaori Kanemaru, Yoshikazu Nakamura
  8. See more Magazine articles

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