2025 Week 10 College Football Predictions for Every Game

Following a relatively quiet weekend around the nation, Week 10 is poised to reinject some chaos into college football.

Twelve of the 20 ranked teams in action are preparing for a road game, headlined by a pair of Top 25 clashes. Oklahoma heads to Tennessee in a battle of SEC survival, and Cincinnati travels to Utah for a critical Big 12 contest.

Additionally, this is the last weekend before the first College Football Playoff ranking is released. It's the final chance to shape a team's formal CFP impression.

Rankings are based on the AP Top 25.

No. 9 Vanderbilt (7-1) at No. 20 Texas (6-2), Noon ET

I would like to quit Texas. The offense is what it is—mediocre at best—and a thorny defense can only survive so long. It would be easier to quit Texas than fully embrace an unprecedented Vandy bandwagon. But the Longhorns, despite their issues, keep figuring out ways to win ugly. The trend continues at home.

Prediction: Texas 27, Vanderbilt 23

No. 10 Miami (6-1) at SMU (5-3), Noon

Miami is a double-digit favorite, but there are serious warning signs here. SMU's defense is 11th nationally in yards allowed per carry, and the Mustangs have snagged 12 interceptions this season. Carson Beck's turnover woes crushed the 'Canes in their recent loss to Louisville. Protect the ball, and Miami probably wins. But a couple of giveaways can swing the result to SMU.

Prediction: Miami 31, SMU 24

Navy (7-0) at North Texas (7-1), Noon

The clogged American race is about to get a big answer—or more uncertainty. I'll project the latter, considering the upside of the North Texas offense. Navy smacked FAU last weekend but otherwise has played a bunch of tight games in conference. North Texas, at home, can snatch a high-scoring win.

Prediction: North Texas 38, Navy 34

No. 18 Oklahoma (6-2) at No. 14 Tennessee (6-2), 7:30 p.m.

I've changed my mind about this SEC contest about six times in the last two hours. Oklahoma had a rough day against Ole Miss but consistently has created havoc, and Tennessee QB Joey Aguilar isn't mobile like Trinidad Chambliss. On the other hand, the Vols can spread out OU's defense to attack the boundaries and limit the impact of the Sooners' talented front.

Prediction: Tennessee 30, Oklahoma 27

No. 17 Cincinnati (7-1) at No. 24 Utah (6-2), 10:15 p.m.

Want to earn a true share of national respect? Win marquee games on the road. Cincinnati is a considerable underdog at Utah, which just steamrolled Colorado behind a powerful rushing attack and lockdown defense. Cincy's balance is respectable, but Utah may be starting to peak at a prime moment.

Prediction: Utah 34, Cincinnati 28

No. 25 Memphis (7-1) at Rice (4-4), Friday, 7 p.m. ET

Two weekends ago, Memphis went on the road and—while an injury to quarterback Brendon Lewis did not help—lost to UAB. Avoiding a similar fate against Rice is imperative for the Tigers' conference hopes. As long as Lewis is leading the offense, though, Memphis should be fine.

Prediction: Memphis 35, Rice 24

Jacksonville State (4-3) at Middle Tennessee (1-6), Wednesday, 7:30 p.m.
Prediction: Jax State 31, MTSU 21

Florida International (3-4) at Missouri State (4-3), Wednesday, 8 p.m.
Prediction: Missouri State 30, FIU 24

Marshall (4-3) at Coastal Carolina (4-3), Thursday, 7:30 p.m.
Prediction: Marshall 33, Coastal Carolina 27

Tulane (6-1) at UTSA (3-4), Thursday, 8 p.m.
Prediction: UTSA 34, Tulane 30

North Carolina (2-5) at Syracuse (3-5), Friday, 7:30 p.m.
Prediction: North Carolina 27, Syracuse 24

Sam Houston (0-7) at Louisiana Tech (4-3), Friday, 8 p.m.
Prediction: Louisiana Tech 26, Sam Houston 10

Penn State (3-4) and No. 1 Ohio State (7-0), Noon ET

Entering the season, we thought it would be a Big Ten-defining game. Fast-forward two months, and this result is hardly in question. Penn State can be stingy defensively, but this offense is facing a serious challenge at OSU.

Prediction: Ohio State 31, Penn State 14

West Virginia (2-6) at No. 22 Houston (7-1), Noon

Rich Rodriguez is facing a serious build at West Virginia, which at least flashed a little life defensively in a six-point loss to TCU. Houston isn't built to run away on the scoreboard but figures to control this Big 12 matchup.

Prediction: Houston 32, WVU 20

No. 16 Louisville (6-1) at Virginia Tech (3-5), 3 p.m.

Virginia Tech will enter with a renewed sense of confidence thanks to clipping Cal last week. Louisville, nevertheless, is a much tougher task. Even if the Cardinals start slowly on the road, their offense ultimately should prevail.

Prediction: Louisville 34, Virginia Tech 24

Duke (4-3) at Clemson (3-4), Noon
Prediction: Clemson 31, Duke 23

Rutgers (4-4) at Illinois (5-3), Noon
Prediction: Illinois 38, Rutgers 27

Central Florida (4-3) at Baylor (4-4), Noon
Prediction: Baylor 34, UCF 30

Army (3-4) at Air Force (2-5), Noon
Prediction: Air Force 24, Army 21

UAB (3-4) at Connecticut (5-3), Noon
Prediction: UConn 37, UAB 24

Buffalo (4-4) at Bowling Green (3-5), Noon
Prediction: Bowling Green 23, Buffalo 21

Arizona State (5-3) at Iowa State (5-3), 1 p.m.
Prediction: Iowa State 27, ASU 23

East Carolina (4-3) at Temple (5-3), 2 p.m.
Prediction: ECU 30, Temple 24

New Mexico (5-3) at UNLV (6-1), 3 p.m.
Prediction: UNLV 33, New Mexico 27

No. 2 Indiana (8-0) at Maryland (4-3), 3:30 p.m. ET

Maryland ripped off a 4-0 start but faded in October, dropping three straight games to conference teams. Although the Terps were competitive in all three losses, their margin for error is nonexistent against IU's elite offense.

Prediction: Indiana 38, Maryland 21

No. 5 Georgia (6-1) vs. Florida (3-4), 3:30 p.m. (in Jacksonville)

Will the Gators get a post-coaching change bump? Billy Napier is gone, so UF's offense will have a different feel on Saturday. The defense is still stingy, but that alone isn't enough to spring an upset.

Prediction: Georgia 27, Florida 16

No. 12 Notre Dame (5-2) at Boston College (1-7), 3:30 p.m.

In six games opposite power-conference teams, Boston College has yielded 6.4 yards per snap and 37.8 points per game. This shouldn't be close.

Prediction: Notre Dame 45, Boston College 17

No. 13 Texas Tech (7-1) at Kansas State (4-4), 3:30 p.m.

This is a perfectly nonsensical moment for Kansas State—a top preseason Big 12 contender that has faltered badly—to show its once-perceived upside. Texas Tech quarterback Behren Morton is back after missing the last two weeks, however, and TTU's defense has been fantastic. Tricky game, but Tech survives.

Prediction: Texas Tech 29, Kansas State 24

No. 15 Virginia (7-1) at Cal (5-3), 3:45 p.m.

Over the last two weeks, Virginia has beaten Washington State and North Carolina by a combined three points. Cal is flawed, for sure, but a cross-country trip for UVA's stumbling offense after a couple of escapes is a real concern.

Prediction: Cal 23, Virginia 19

Pitt (6-2) at Stanford (3-5), 3:30 p.m.
Prediction: Pitt 31, Stanford 17

Michigan State (3-5) at Minnesota (5-3), 3:30 p.m.
Prediction: Minnesota 27, MSU 23

Delaware (4-3) at Liberty (3-4), 3:30 p.m.
Prediction: Liberty 28, Delaware 26

New Mexico State (3-4) at Western Kentucky (6-2), 3:30 p.m.
Prediction: WKU 34, NMSU 24

Fresno State (5-3) at Boise State (6-2), 3:30 p.m.
Prediction: Boise State 33, Fresno State 20

Old Dominion (5-3) at Louisiana-Monroe (3-5), 3:30 p.m.
Prediction: ODU 35, ULM 21

Louisiana (2-6) at South Alabama (2-6), 3:30 p.m.
Prediction: South Alabama 27, Louisiana 22

Oklahoma State (1-7) at Kansas (4-4), 4 p.m.
Prediction: Kansas 41, Oklahoma State 20

Mississippi State (4-4) at Arkansas (2-6), 4 p.m.
Prediction: Mississippi State 42, Arkansas 37

Central Michigan (5-3) at Western Michigan (4-4), 4 p.m.
Prediction: CMU 23, WMU 19

South Carolina (3-5) at No. 7 Ole Miss (7-1), 7 p.m. ET

Despite its record, South Carolina has been a pest for much of SEC action. Ole Miss needs to avoid a hangover game following a massive win at Oklahoma, too. Mix that together, and there's potential for an ugly first half. Eventually, though, Ole Miss should be able to outlast what's been a frustrating SC offense.

Prediction: Ole Miss 31, South Carolina 20

Purdue (2-6) at No. 21 Michigan (6-2), 7 p.m.

Losers of six straight games, Purdue is searching for answers defensively. Rutgers is the only Big Ten program worse at preventing explosive gains. If Michigan finds a few of those big plays, it'll be a blowout.

Prediction: Michigan 34, Purdue 17

No. 8 Georgia Tech (8-0) at North Carolina State (4-4), 7:30 p.m.

Notre Dame and Pitt combined to put up 755 passing yards in NC State's last two outings. Georgia Tech is a run-focused team, yet Haynes King has been impressively efficient lately as a passer. NC State springing an upset—and throwing a major wrench in the ACC—would be a remarkable reversal of trends.

Prediction: Georgia Tech 30, NC State 20

No. 23 USC (5-2) at Nebraska (6-2), 7:30 p.m.

Speaking of trends, Nebraska has finished below five yards per snap in five of its six games against power-conference teams. One major reason is a pass defense that has surrendered a mere 5.0 yards per attempt and three scores to five interceptions. In short: I think USC wins anyway. But if Nebraska's chief strength doesn't show up, this could be a long night in Lincoln.

Prediction: USC 34, Nebraska 27

Arizona (4-3) at Colorado (3-5), 7 p.m.
Prediction: Arizona 36, Colorado 20

Wyoming (4-4) at San Diego State (6-1), 7 p.m.
Prediction: SDSU 23, Wyoming 17

Wake Forest (5-2) at Florida State (3-4), 7:30 p.m.
Prediction: Florida State 27, Wake Forest 22

Kentucky (2-5) at Auburn (4-4), 7:30 p.m.
Prediction: Auburn 24, Kentucky 19

Washington State (4-4) at Oregon State (1-7), 7:30 p.m.
Prediction: Washington State 30, Oregon State 24

Arkansas State (4-4) at Troy (6-2), 8 p.m.
Prediction: Troy 28, Arkansas State 23

Hawaii (6-2) at San Jose State (2-5), 10:30 p.m.
Prediction: Hawaii 33, SJSU 26